Genes & Diseases Journal

Genes & Diseases Journal Genes & Diseases publishes research on the molecular basis and therapeutics of human diseases. (IF: 9.4; Scopus CiteScore: 8.4)

Formats include full-length articles, reviews, short communications, and more.

Treating may require targeting more than a single pathway. This review examines why -directed therapies have shown li...
10/08/2026

Treating may require targeting more than a single pathway.

This review examines why -directed therapies have shown limited clinical success, identifies co-targeting partners that could improve treatment efficacy, and highlights combination strategies and -based delivery systems that may enable more precise, personalized therapies for EGFR-high TNBC. Agnieszka Robaszkiewicz International Students Office - University of Lodz

in : https://doi.org/10.1016/j.gendis.2025.102026

Next-generation depend on uncovering new ways to eliminate tumor cells. This review explores , a newly identified for...
09/08/2026

Next-generation depend on uncovering new ways to eliminate tumor cells.

This review explores , a newly identified form of regulated cell death, highlighting its signaling mechanisms, potential, and emerging role as a promising target for precision cancer diagnosis and treatment. Henan University - 河南大学 - Hénán Dàxué

in : https://doi.org/10.1016/j.gendis.2025.102028

What if controlling protein fate could change the course of ?This review explores how regulate key pathways driving a...
09/08/2026

What if controlling protein fate could change the course of ?
This review explores how regulate key pathways driving atherosclerosis, cardiac remodeling, arrhythmia, hypertension, and ischemia/reperfusion injury, highlighting as a promising target for future cardiovascular therapies.
in : https://doi.org/10.1016/j.gendis.2025.102023

Understanding requires connecting evidence across genetics, immunity, and clinical research.This review examines the s...
09/08/2026

Understanding requires connecting evidence across genetics, immunity, and clinical research.

This review examines the strengths and limitations of current , summarizes advances in disease mechanisms and treatment strategies, and provides a practical framework to guide future studies toward more effective therapies for this complex . %20Medical%20University

in : https://doi.org/10.1016/j.gendis.2025.102022

in people with diabetes remains poorly understood, limiting opportunities for early prevention.This study uncovers a c...
08/08/2026

in people with diabetes remains poorly understood, limiting opportunities for early prevention.

This study uncovers a causal link between and , identifying shared genes, gut microbiota, and metabolic traits that provide new insight into disease mechanisms and open avenues for targeted preventive strategies.

in : https://doi.org/10.1016/j.gendis.2025.102019

may be more than bystanders in disease.This review frames TGM2 and related isoenzymes as a TG–pathology axis, linkin...
08/08/2026

may be more than bystanders in disease.

This review frames TGM2 and related isoenzymes as a TG–pathology axis, linking proteostasis disruption and neuroimmune activation to protein aggregation, inflammation, and cell death, while highlighting isoform‑specific roles, therapeutic strategies, and barriers to translation in neurodegenerative and neuroinflammatory disorders.

in : https://doi.org/10.1016/j.gendis.2026.102392

Can the rescue the brain?This preclinical study identifies circulatory proteins that regulate risk, spotlighting FCN...
07/08/2026

Can the rescue the brain?

This preclinical study identifies circulatory proteins that regulate risk, spotlighting FCN2 as a protective factor whose replenishment in mice restored cognition, reduced pathology, and enhanced synaptic homeostasis, revealing a liver‑to‑brain axis where peripheral proteins shape and therapeutic potential. Tongji University

in : https://doi.org/10.1016/j.gendis.2026.102391

How sustains itself is now clearer.This study uses and coculture models to reveal reciprocal crosstalk between macro...
07/08/2026

How sustains itself is now clearer.

This study uses and coculture models to reveal reciprocal crosstalk between macrophages and fibroblast‑like , showing how SEMA4A/PLXNB2 and GAS6–MERTK signaling drive invasiveness and M2 polarization, identifying candidate targets to disrupt this pathogenic loop. Central South University 中南大学

in : https://doi.org/10.1016/j.gendis.2026.102386

Why do lenses age into ?This study identifies as a crucial safeguard against , showing that its decline accelerates ...
07/08/2026

Why do lenses age into ?

This study identifies as a crucial safeguard against , showing that its decline accelerates lens epithelial cell senescence through mitochondrial dysfunction and epigenetic injury, while genetic and pharmacologic disruption of APE1 pathways consistently triggered opacity—spotlighting APE1 as a therapeutic target for early intervention in ARC.

in : https://doi.org/10.1016/j.gendis.2026.102384

Healthy gut function depends on more than digestion—it relies on precise cellular signaling. This review highlights how ...
06/08/2026

Healthy gut function depends on more than digestion—it relies on precise cellular signaling.

This review highlights how orchestrate gastrointestinal development, tissue homeostasis, and repair, while revealing how ciliary dysfunction contributes to congenital , inflammatory bowel disease, and , positioning ciliary signaling as a promising therapeutic frontier. Zhejiang University

in : https://doi.org/10.1016/j.gendis.2026.102389

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