Genes & Diseases Journal

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Genes & Diseases Journal Genes & Diseases publishes research on the molecular basis and therapeutics of human diseases. (IF: 9.4; Scopus CiteScore: 8.4)

Formats include full-length articles, reviews, short communications, and more.

is more than a metabolic disease.This review highlights how creates lasting changes in that may drive diabetes pro...
14/10/2026

is more than a metabolic disease.

This review highlights how creates lasting changes in that may drive diabetes progression and its complications, revealing a previously underappreciated link between metabolic dysfunction and immune memory while pointing to new therapeutic opportunities beyond glucose control. Southwest Medical University

in : https://doi.org/10.1016/j.gendis.2025.101940

-driven liver cancer may be written in non-coding RNA.As chronic hepatitis B remains a leading cause of , this review ...
13/10/2026

-driven liver cancer may be written in non-coding RNA.

As chronic hepatitis B remains a leading cause of , this review highlights how dysregulated influence viral replication and tumour development, revealing promising biomarkers for early detection and potential therapeutic targets that could improve outcomes in HBV-associated liver cancer. Yunnan University

in : https://doi.org/10.1016/j.gendis.2025.101878

Could reactivating a silenced X chromosome transform treatment for ?This review examines how skewed influences diseas...
13/10/2026

Could reactivating a silenced X chromosome transform treatment for ?

This review examines how skewed influences disease severity, methods for quantifying XCI, and emerging Xist-targeted strategies that could reactivate silenced alleles, improve risk assessment and advance . Central South University 中南大学

in : https://doi.org/10.1016/j.gendis.2025.101964

may do far more than regulate T-cell immunity. This review examines its emerging expression and functions in cells, ...
12/10/2026

may do far more than regulate T-cell immunity.

This review examines its emerging expression and functions in cells, fibroblasts, and endothelial cells, highlighting roles in metabolism, mitochondrial function, tissue regeneration and signaling crosstalk while identifying key gaps in understanding its noncanonical regulation.

in : https://doi.org/10.1016/j.gendis.2026.102523

Interpreting rare-disease variants remains a major barrier to accurate diagnosis and treatment.This review explores how ...
12/10/2026

Interpreting rare-disease variants remains a major barrier to accurate diagnosis and treatment.

This review explores how can strengthen research through variant classification, , EHR analysis, radiomics and therapy optimization, while highlighting data, model and ethical challenges. UAEU_News

in : https://doi.org/10.1016/j.gendis.2026.102520

Could a single RNA modification shape muscle growth before birth?While disrupts muscle development, this study identif...
12/10/2026

Could a single RNA modification shape muscle growth before birth?

While disrupts muscle development, this study identifies m7G methylation as a key regulator of protein synthesis, revealing that the METTL1-eIF3a pathway supports by maintaining translational capacity and highlighting a new mechanism underlying developmental impairment. 四川大学

in : https://doi.org/10.1016/j.gendis.2026.102519

Could move treatment beyond lifelong ? This review examines , base and prime editing, viral and non-viral gene rep...
12/10/2026

Could move treatment beyond lifelong ?

This review examines , base and prime editing, viral and non-viral gene replacement, and mRNA therapies designed to restore hepatic PAH activity, while highlighting key challenges in delivery, safety, durability and patient stratification on the path toward personalized, potentially curative treatment.

in : https://doi.org/10.1016/j.gendis.2026.102522

One RNA-modifying enzyme could influence cancer across multiple tumor types.This review examines how FTO’s demethylase...
11/10/2026

One RNA-modifying enzyme could influence cancer across multiple tumor types.

This review examines how FTO’s demethylase activity can either drive or suppress cancer through diverse molecular mechanisms, revealing its context-dependent roles and highlighting FTO as a promising target for . Huazhong University of Science and Technology

in : https://doi.org/10.1016/j.gendis.2026.102210

Could lactate-driven changes determine how the heart recovers after ?This review explores how histone lysine intera...
11/10/2026

Could lactate-driven changes determine how the heart recovers after ?

This review explores how histone lysine interacts with acetylation, phosphorylation, m6A methylation and ubiquitination to regulate cell death during myocardial ischemia/reperfusion injury, revealing promising targets for cardioprotection. China Three Gorges University -Yichang,Hubei,China

in : https://doi.org/10.1016/j.gendis.2026.102211

Could help overcome treatment resistance in ?This review examines how miRNAs and anti-miRs regulate apoptosis and sha...
11/10/2026

Could help overcome treatment resistance in ?

This review examines how miRNAs and anti-miRs regulate apoptosis and shape responses to radiotherapy and chemotherapy, identifying miRNA-based radiosensitizers, mechanisms and potential therapeutic targets to improve treatment outcomes in breast cancer.
university -of-medical-sciences

in : https://doi.org/10.1016/j.gendis.2025.102024

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