19/04/2026
Amazing post by Dr Helen Wall ! Check out her page!
"This is still sooo underrecognied in healthcare. Iām trying to get this on everyoneās minds. This may be the first time a woman presents when her hormones unravel and the capacity to keep masking slips away.
Neurodivergence (ADHD, autism etc) can be affected by hormonal fluctuations due to the interaction between hormones and the brainās functioning via chemical messengers. This is basic neuroscience so why do we not discuss it more?
1. Hormonal Sensitivity and the Brain
Oestrogen and progesterone levels fluctuate throughout the menstrual cycle, during pregnancy, and during menopause. These hormones influence neurotransmitter systems/ chemical messengers like serotonin, dopamine, and GABA, which regulate mood, focus, and energy. Neurodivergence (e.g., ADHD, autism, dyspraxia) often involve atypical neurotransmitter activity, making fluctuations more noticeable.
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Oestrogenās Role: High estrogen levels (e.g., before ovulation) can enhance focus and mood, while low levels (e.g., premenstrual phase) may worsen executive dysfunction, emotional regulation, and sensory sensitivities.
2. Premenstrual Syndrome (PMS) and PMDD
For some women, premenstrual syndrome (PMS) or its more severe form, premenstrual dysphoric disorder (PMDD), can amplify neurodivergent traits. This happens due to the drop in oestrogen and serotonin levels, leading to heightened emotional sensitivity, irritability, or difficulty concentrating.
3. Cortisol and Stress
Hormonal shifts can increase cortisol (the stress hormone) levels, particularly during the luteal phase of the menstrual cycle. For neurodivergent individuals, stress responses may already be heightened, so this can exacerbate traits like anxiety, sensory overload, or difficulty managing change.
4. Menopause
During menopause, declining oestrogen levels and increased hormonal instability can worsen cognitive challenges, emotional regulation, and sensory issues, particularly exacerbating neurodivergence.
The diagnostic criteria and clinical view of things like ADHD is through a male gaze. So many women hit perimenopause undiagnosed and totally unravel. Itās not fair. Help me spread the word"