Recurrent Miscarriage Clinic London

Recurrent Miscarriage Clinic London At our clinic, we provide a fully comprehensive clinical service to women who have suffered from rec

It was the ‘International Clinical Trials Day’ last week. Celebrated annually on May 20, this day commemorates the anniv...
28/05/2026

It was the ‘International Clinical Trials Day’ last week. Celebrated annually on May 20, this day commemorates the anniversary of James Lind’s 1747 scurvy study, widely recognised as the first randomised controlled clinical trial.

As Helen Pearson writes in this fascinating book - the term evidence based medicine is barely 35 years old. She demonstrates how adherence to good evidence is critical when it comes to the field of medicine.

As Michael Marshall writes in the New Scientist - it was the situation where women with the same condition had wildly different advice from two different doctors that led Iain Chalmers and Archie Cochrane to generate systematic reviews and meta-analyses and demonstrate the importance of good quality evidence for safety and efficacy of medical interventions.

In today’s era of widespread misinformation and advice based on cherry-picked evidence and personal experience - it is ever more important for healthcare professionals to standby the need for robust clinical evidence before any clinical interventions are recommended. Where there is paucity of evidence- it needs clear discussion. Research can take long and use up resources but where it needs to be done, it must be done properly!

https://www.newscientist.com/article/mg27035940-700-what-to-read-this-week-the-excellent-beyond-belief-by-helen-pearson/

https://pubmed.ncbi.nlm.nih.gov/23543706/

PMOS and PerimenopauseWe have had plenty of news this week about Polyendocrine Metabolic Ovarian Syndrome (PMOS) which i...
16/05/2026

PMOS and Perimenopause

We have had plenty of news this week about Polyendocrine Metabolic Ovarian Syndrome (PMOS) which is the new name for the condition previously known as Polycystic O***y Syndrome (PCOS), which impacts 1 in 8, or more than 170 million women worldwide.

Here is some more. Previous research studies on PCOS and age of onset of natural menopause transition have revealed conflicting results - few suggesting a delayed age of onset of transition and other studies or systematic reviews suggesting the same average age of onset of menopause.

This study from Johanna Lavi et al. highlighted by the New Scientist focusses on a new study which used data from 1849 women from Northern Finland Birth Cohort study. By the age of 46, Only 3 percent of 380 women diagnosed with PCOS had reached established perimenopause or menopause compared with 18 percent of non-PCOS women. The authors suggested that this was likely an effect of larger ovarian reserve.
Women with PCOS more often reported having regular menstrual cycles and had a lower risk of menopausal symptoms at age 46, even after adjusting for body mass index, education, and smoking status (adjusted odds ratio 0.68, 95% confidence interval 0.51–0.92). Hot flushes and sleep disturbances were less frequent among women with PCOS, but there were no differences in other menopause-related symptoms.

Strengths of the study - population-based and included an unselected population and a wide range of measurements. Limitations- lack of diverse ethnic backgrounds, reliance on a single randomly timed FSH measurement and potential bias related to progestin use and FSH levels.

We are beginning to understand the menopause transition on background of PCOM better - still plenty more to find out!

https://www.newscientist.com/article/2525632-pcos-postpones-perimenopause-and-allows-pregnancies-at-older-ages/

https://obgyn.onlinelibrary.wiley.com/doi/10.1111/aogs.70198

It was wonderful to catch up with you this week, Aziza.A big thanks for the keyring gift. Please support Aziza’s amazing...
15/05/2026

It was wonderful to catch up with you this week, Aziza.
A big thanks for the keyring gift. Please support Aziza’s amazing work to fund Menstrual Health Workshops in Sierra Leone to empower women and girls with the knowledge about their menstrual health and make their own period pads.
https://www.talkswithdrsesay.com/shop

PCOS affects many of the patients we see, yet care is often inconsistent.Evidence in this field continues to evolve and ...
13/05/2026

PCOS affects many of the patients we see, yet care is often inconsistent.

Evidence in this field continues to evolve and PCOS will be known as PMOS now.

I’ll be speaking at PCOS TIME 2026, a course focused on improving diagnosis, management and patient outcomes.

📅 21–22 May | Online

Details here:
🔗 https://www.verity-pcos.org.uk/pcostime.html

Do join us if you can

Polyendocrine Metabolic Ovarian Syndrome (PMOS) is the new name for the condition previously known as Polycystic O***y S...
12/05/2026

Polyendocrine Metabolic Ovarian Syndrome (PMOS) is the new name for the condition previously known as Polycystic O***y Syndrome (PCOS), which impacts 1 in 8, or more than 170 million women worldwide.

https://www.mchri.org.au/wp-content/uploads/2026/05/Language-translation-V3-12-May.pdf

* Doctors may use Anti-Muellerian Hormone levels instead of ultrasound to diagnose PCOS in adults.
* PCOS carries an increased risk of diabetes and heart disease, but this risk can be reduced by screening and prevention including a healthy lifestyle.
* PCOS is linked to sleep apnoea, which affects breathing and sleep quality and can cause tiredness.
* PCOS is associated with endometrial cancer, however overall risks are low hence regular monitoring is not routinely recommended.
* PCOS is linked to mental health challenges, including depression and anxiety. Monitoring and early support are recommended. Social experiences, like weight stigma and challenges related to facial and body hair and/or severe acne, may contribute to these mental health issues in PCOS.
* To manage PCOS, focus on healthy habits. Being as active as possible and eating healthy foods most of the time is still the best medicine for PCOS.
* Laser and light therapy for reducing unwanted hair caused by PCOS are good options for those with suitable skin and hair colour.
* PCOS is considered a high-risk condition during pregnancy. Doctors need to be aware of PCOS and closely monitor and prevent potential risks.
* Higher weight can affect fertility and pregnancy health and support for a healthy lifestyle is important.
* If experiencing difficulty getting pregnant, there are very good treatments available and for most with PCOS this only requires tablet therapy.

https://mchri.org.au/wp-content/uploads/2023/08/10-new-things.pdf

A big Thank you!International Nurses Day 2026A big shout out and Happy International Nurses Day to all our nursing colle...
12/05/2026

A big Thank you!
International Nurses Day 2026

A big shout out and Happy International Nurses Day to all our nursing colleagues and friends who always go above and beyond to deliver the best possible care to their patients!

The Nurses Day is celebrated on 12th May each year, to coincide with the birthday of Florence Nightingale, and since 1988 has been given a theme by the International Council of Nurses.

There is a need for more investment in nursing, improving working conditions and safety for nurses, growing the size of the workforce and improving nursing education across the world.

Here is a survey from Menopause and Cancer CIC (not-for-profit) designed to gather insights from individuals (age 18-30)...
02/05/2026

Here is a survey from Menopause and Cancer CIC (not-for-profit) designed to gather insights from individuals (age 18-30) who have experienced both menopause and cancer with the aim to better understand the unique challenges faced by this community and to use these findings to enhance the support available for those affected.

The survey is conducted by Menopause and Cancer, an organisation dedicated solely to supporting people navigating menopause after cancer.

All responses are completely anonymous. You must be aged 18-30 years old to take part in this survey. If you have any questions, comments, or concerns, please contact us at: [email protected]. Thank you Dani Binnington and Phoebe Cardew for setting this up.

Please participate in the survey if you can or share with those who may be interested. Thank you for contributing to this research 🙏🏼.

Research Survey About Menopause After Cancer (18-30 years old) – Fill in form
https://gbr01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fforms.cloud.microsoft%2FPages%2FResponsePage.aspx%3Fid%3D8y1ywoOIqkup1ZOI4kKt2B5ITslOQvhElyTxa010jzlUNUgxWjYxOUtOU1NER0hJNEdDQzZEQ0dJTSQlQCN0PWcu&data=05%7C02%7Cvikram.talaulikar%40nhs.net%7C3be4b2a4efa34ba88e5f08dea756b676%7C37c354b285b047f5b22207b48d774ee3%7C0%7C0%7C639132188107965552%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=8VGY4xeg5sIdhTrv1IGG5kUdqrPEPy4HFW2n9LO8WI8%3D&reserved=0

PCOS affects many of the patients we see, yet care is often inconsistent. I’ll be speaking at PCOS TIME 2026, a course f...
28/04/2026

PCOS affects many of the patients we see, yet care is often inconsistent.

I’ll be speaking at PCOS TIME 2026, a course focused on improving diagnosis, management and patient outcomes.

📅 21–22 May | Online

Details here:
🔗 https://www.verity-pcos.org.uk/pcostime.html

Do join us if you can

Here is a Phase 2, Randomised, Double-blind, Placebo-controlled Trial to Investigate the Efficacy and Safety of 2 Doses ...
20/04/2026

Here is a Phase 2, Randomised, Double-blind, Placebo-controlled Trial to Investigate the Efficacy and Safety of 2 Doses of Vipoglanstat in Patients With Moderate to Severe Endometriosis-related Pain - the NOVA Trial.
Vipoglanstat is being developed as an oral, non-hormonal, non-opioid medicine for treating symptoms of endometriosis, such as pain during and between menstrual periods.
Vipoglanstat blocks the action of a specific enzyme called microsomal prostaglandin E synthase-1 (mPGES-1). This enzyme is important for the development of endometriosis and causes both pain and
inflammation. Vipoglanstat has been tested in endometriosis disease models, where it
significantly reduced both pain and endometriotic lesions. Vipoglanstat is considered an ‘investigational’ medication in this study because it is in development and has not been approved for endometriosis-related pain by the MHRA (Medicines and Healthcare products Regulatory Agency).
The study is aiming to recruit around 380 women into this study in around 50 study sites in the European Union and the United Kingdom. Participants will be in the study for about 6 to 10 months, depending on their current treatment for endometriosis-related symptoms.
Do support it share information about the study with those who may be interested.
Contact details for study -
[email protected]
T: 0117 414 8102 / 0117 414 8136 (Clinical Research Centre), North Bristol NHS Trust, Southmead Hospital, Bristol

https://clinicaltrials.gov/study/NCT07260669

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