08/01/2026
Here’s what I’m taking from the new BMJ systematic review + meta-analysis (7 Jan 2026) on weight regain after stopping weight-management medications:
When people stop anti-obesity meds (including GLP-1/GIP-GLP-1 injections), weight regain is the norm, not the exception. Across 37 studies (9,341 people), the average pattern was a steady return towards baseline — roughly 0.4 kg per month after stopping, with a full return to baseline predicted around ~1.7 years. 
For GLP-1 medications specifically (e.g., semaglutide/tirzepatide), regain looked faster per month (~0.8 kg/month) — but because initial losses are often larger, the time back to baseline was still around ~1.5 years. 
And it’s not just weight: improvements in markers like blood pressure and cholesterol tended to drift back too (around ~1.4 years). 
Appetite Club takeaway: this isn’t a “lack of willpower” story — it’s a biology + environment + chronic condition story. If a medication is part of your care, it deserves a long-term plan (including what “maintenance” looks like, and what support you’ll have if you ever come off). And if you are coming off, this is exactly where we focus: rebuilding trustworthy appetite regulation without sliding into restriction-rebound cycles. 💛 
(Always speak to your prescriber before changing any medication.)