24/06/2026
A study presented at ENDO 2026 looked at activity levels in adults after they started taking GLP-1 medication, using Fitbit data to track their movement patterns. What they found was interesting, people did not automatically become more active. In fact, their activity appeared to go down.
Average daily steps dropped from around 5,047 to 4,487 per day, and MVPA dropped from 28 to 22 minutes per day. Now, doesn’t sound dramatic, however it’s worth thinking about what happens when appetite drops and calorie intake reduces.
When in a calorie deficit (GLP or not), your body may respond by conserving energy. It’s known as adaptive thermogenesis and is almost a natural byproduct of the deficit.
This can show up as a reduction in spontaneous movement across the day, non-exercise activity thermogenesis, or NEAT. This includes things like walking around, doing jobs, standing more, fidgeting, taking the stairs, and generally moving without formally “exercising.”
Most people won’t notice this happening. They don’t wake up and decide to move less. It is often subtle. You sit a bit more, you take fewer incidental steps, you feel less inclined to do the extra walk, or you just naturally conserve energy because your brain is trying to match lower energy intake with lower energy output.
Over time, this can lead to a diminishing of a deficit and a stall.
GLP-1 medications need to come with a plan. It needs to be intentional.
Start exercising while on the medication and build that habit, as it won’t happen by itself. The press release (this hasn’t been published) rightly pointed out that just losing weight isn’t going to make someone more active.
A good plan should include strength training to help protect lean mass, enough protein to support muscle and nutrient intake (min 1.2g/kg bw), and some kind of daily movement target so steps and incidental activity don’t drop away.
And, exercise is life. Really. The best way to feel better is to exercise (though if currently sedentary, this is a hard sell I know!) And no shade on anyone who physically CAN’T exercise.
https://www.endocrine.org/news-and-advocacy/news-room/2026/maharjan-press-release-e