21/05/2026
Collagen gets called a “low-quality protein” a lot, and technically, that is true if we are judging it by the same criteria we use for building muscle.
If your goal is muscle protein synthesis, collagen is not what you use.
Not all proteins need to do the same job.
Collagen is rich in glycine, proline and hydroxyproline, amino acids that are heavily represented in connective tissue. This makes collagen more relevant when we are talking about skin, nails, tendons, ligaments, cartilage and bone matrix, rather than just “does this spike muscle protein synthesis?”
And this is why I recommend it.
The clinical research on skin is reasonably consistent. Systematic reviews and meta-analyses of randomised controlled trials have found that oral collagen supplementation can improve skin hydration, elasticity and wrinkles, particularly when taken consistently over 8–12 weeks or longer. Is it going to reverse ageing? No. But can it modestly support skin structure and hydration? The evidence suggests yes.
For nails, there is research showing that specific bioactive collagen peptides can improve brittle nails, increasing nail growth and reducing broken nails. That may not sound earth-shattering, but for women dealing with splitting, peeling or weak nails, it may be useful.
Where collagen becomes especially interesting is in active people and midlife athletes. Research from the Ormsbee lab found that 10 g per day of collagen peptides over 6–9 months improved measures of activities of daily living, pain, and physical or mental health outcomes in middle-aged active adults. That matters because many people over 40 are not limited by motivation. They are limited by whether their knees, hips, Achilles, shoulders or tendons will let them keep doing the thing they love.
Professor Keith Baar’s work is also important here. His research has shown that gelatin or collagen combined with vitamin C before loading exercise can increase markers of collagen synthesis.
That is the key point: collagen is not magic. But it may be a useful targeted tool.
PMID 37432180, 33742704, 28786550, 37551682, 27852613, 34808597