08/06/2026
Some interesting new research... still in it's early days, but nice to see this being looked at from a scientific point of view. If you are having any issues or doubts about your supply, please reach out to us for help đź’š
A 2024 study, published in Nature Communications and highlighted by UC Santa Cruz, found that triggering DNA damage responses during pregnancy stimulates endoreplication—a process where mammary alveolar cells increase their ploidy—resulting in higher, non-hormonal milk production. The study identified that the kinase WEE1 is crucial in regulating this process.
Key findings from the study include:
Mechanism: Increased DNA damage and replication stress during pregnancy trigger a response that boosts the development of milk-producing cells.
WEE1 Kinase Role: The study identified that WEE1 mediates early mitotic arrest, a critical step in establishing the necessary cell population for milk production.
Non-Hormonal Pathway: Inhibiting CDK1 (via methods like inhibiting the WEE1 kinase pathway) was found to increase endoreplication and improve milk production.
Impact: This research provides a novel therapeutic target for treating lactation insufficiency syndrome.
National Institutes of Health (.gov) +4
This research highlights that, rather than solely relying on hormonal changes, controlling the cell cycle and DNA damage response in mammary cells can directly increase milk production.
https://www.facebook.com/share/p/18Ga1NwUGU/
UC Santa Cruz scientists reveal new path to increasing lactation for nursing mothers
Naturally occurring DNA damage during pregnancy triggers creation of more milk-producing cells
April 19, 2024 By Mike Peña
https://news.ucsc.edu/2024/04/lactation-endoreplication.html
Reference:
Molinuevo, R., Menendez, J., Cadle, K. et al. Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation. Nat Commun 15, 3288 (2024). https://doi.org/10.1038/s41467-024-47668-9