22/09/2025
G-Zolecap 20/40mg (Omeprazole)
Omeprazole
Description: Omeprazole is the active ingredient in both 20 mg and 40 mg capsule. It is a proton pump inhibitor that reduces stomach acid production by inhibiting the H+/K+ ATPase enzyme in the gastric lining.
Function: Provides relief from conditions caused by excessive stomach acid, such as GERD, peptic ulcers, and Zollinger-Ellison syndrome.
1. Product Description
Name: G-Omozol 20/40mg (Omeprazole)
Type: Proton Pump Inhibitor (PPI)
Form: Oral capsule
Strength: Available in 20 mg and 40 mg per capsule
2. Chemical Information
Chemical Name: Omeprazole
Molecular Formula: C17_{17}17H19_{19}19N3_{3}3O3_{3}3
Molecular Weight: Approximately 345.35 g/mol
3. Indications
Primary Uses:
Treatment of gastroesophageal reflux disease (GERD)
Healing of erosive esophagitis caused by gastroesophageal reflux disease (GERD)
Management of Zollinger-Ellison syndrome (a condition where the stomach produces excessive acid)
Treatment of peptic ulcers, including those caused by Helicobacter pylori infection, often in combination with antibiotics
4. Dosage and Administration
Dosage Forms:
Omeprazole 20 mg: Typically used for standard indications such as GERD and peptic ulcers.
Omeprazole 40 mg: Used for more severe conditions or where higher doses are needed, such as Zollinger-Ellison syndrome or severe GERD.
Typical Dosage Schedule:
20 mg: Usually once daily before a meal. Can be taken up to twice daily for severe conditions.
40 mg: Typically once daily, but can be taken up to twice daily as required.
Administration: Swallow capsules whole with a full glass of water. Do not crush, chew, or break the capsules.
5. Pharmacokinetics
Absorption: Omeprazole is well absorbed from the gastrointestinal tract. Peak plasma concentrations occur approximately 1 to 2 hours after oral administration.
Distribution: It is extensively bound to plasma proteins.
Metabolism: Metabolized primarily in the liver via the cytochrome P450 enzyme system (CYP2C19 and CYP3A4).
Excretion: Excreted mainly in the urine, with a smaller amount eliminated via bile.
6. Side Effects
Common Side Effects:
Gastrointestinal symptoms (e.g., nausea, vomiting, diarrhea)
Headache
Dizziness
Serious Side Effects:
Risk of Clostridium difficile infection in the colon
Risk of bone fractures with long-term use
Kidney issues (e.g., acute interstitial nephritis)
Hypomagnesemia (low magnesium levels)
7. Contraindications
Known Allergies: Hypersensitivity to omeprazole or other PPIs.
Liver Disease: Severe hepatic impairment.
Drug Interactions: Caution with drugs that interact with CYP2C19, such as clopidogrel.
8. Precautions
Caution: Use with caution in patients with a history of liver disease, renal impairment, or those who are pregnant or breastfeeding.
Drug Interactions: May interact with drugs metabolized by CYP2C19 and CYP3A4. Inform your healthcare provider about all medications you are taking.
Monitoring: Regular monitoring of magnesium levels and bone density may be necessary during long-term therapy.
9. Storage
Conditions: Store at room temperature, away from moisture and heat.
Packaging: Typically found in blister packs or bottles with child-resistant caps.
10. Patient Counseling Information
Adherence: Take as prescribed and do not exceed the recommended dose.
Timing: Best taken before a meal, usually in the morning.
Report Symptoms: Notify your healthcare provider if you experience severe side effects or signs of an allergic reaction, such as rash, itching, or swelling.
