01/09/2026
This is one of the biggest gender differences in medicine.
About 1 in 5 women will have Migraine in their lifetime.
Compared to only about 1 in 15 men.
Because Migraine is a genetic neurological disorder.
In other words, Migraine runs in families.
And some of the genes linked to it appear to be more active in women.
But that is not the full picture...
Because before puberty boys and girls get Migraine attacks at the same rate.
So, this is not ONLY about being a woman...
Instead, it's also about estrogen.
In the brain, there is a nerve pathway called the trigeminovascular system.
When this is triggered, it causes a migraine attack.
Estrogen controls how easily this system turns on.
In other words...
When estrogen levels are high and steady, the system stays calm.
And when estrogen drops suddenly, the system activates.
This is why many women get Migraine attacks right before their period.
Estrogen falls fast in those 2 to 3 days.
It is also why migraines get worse for some women during perimenopause.
Because this is when estrogen levels rise and fall without warning.
In simpler terms...
Hormone change → Lower migraine threshold → Trigeminal activation → Migraine attack.
So, it is not that women are simply “more sensitive to pain.”
Instead, the female brain and migraine pathways are affected by changes in estrogen.
And let's not foget about sleep and stress load...
Women often get less restful sleep and carry more daily stress.
Because, in many families, women do most of the caregiving.
Many also work shifts that break up normal sleep.
And both poor sleep and high stress are well-known Migraine triggers.
That is why migraine is 3 times more common in women.
And also why women with migraine experience attacks that are...
Longer, more disabling, and more likely to include nausea and vomiting.
P.S. Do you get Migraine attacks around your hormonal cycle?
P.P.S. If you need help with your migraine or would like a second opinion, feel free to WhatsApp me on 0321 5615880
Dr Azrung Fayaz
Neurologist