25/04/2026
𝗣𝗲𝗿𝘀𝗶𝘀𝘁𝗲𝗻𝘁 & 𝗜𝗻𝘁𝗿𝗮𝗰𝘁𝗮𝗯𝗹𝗲 𝗛𝗶𝗰𝗰𝘂𝗽𝘀
Most cases = 𝗡𝗢 𝗗𝗥𝗨𝗚𝗦
➤ Short duration (48 hours
Intractable hiccups
➤ >1 month
𝗙𝗶𝗿𝘀𝘁 𝗦𝘁𝗲𝗽 (𝗠𝗢𝗦𝗧 𝗜𝗠𝗣𝗢𝗥𝗧𝗔𝗡𝗧)
𝗧𝗿𝗲𝗮𝘁 𝘂𝗻𝗱𝗲𝗿𝗹𝘆𝗶𝗻𝗴 𝗰𝗮𝘂𝘀𝗲
Common causes:
➤ Gastroesophageal Reflux Disease
➤ CNS: stroke, tumor, infection
➤ Diaphragmatic irritation (pneumonia, subphrenic abscess)
➤ Post-operative state
➤ Metabolic: uremia, hyponatremia, hypocalcemia
➤ Drugs: steroids, benzodiazepines, chemotherapy
𝗪𝗵𝗲𝗻 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗜𝘀 𝗡𝗲𝗲𝗱𝗲𝗱
Persistent (>48h) OR distressing hiccups
𝗚𝗼𝗹𝗱 𝗦𝘁𝗮𝗻𝗱𝗮𝗿𝗱
Chlorpromazine = 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗼𝗳 𝗖𝗵𝗼𝗶𝗰𝗲
➤ 25–50 mg PO / IM / IV
➤ Only FDA-approved drug
➤ Side effects: sedation, hypotension
𝗠𝗼𝗱𝗲𝗿𝗻 𝗣𝗿𝗮𝗰𝘁𝗶𝗰𝗲 𝗣𝗿𝗲𝗳𝗲𝗿𝗿𝗲𝗱
Baclofen = 𝗙𝗶𝗿𝘀𝘁 𝗰𝗵𝗼𝗶𝗰𝗲 (clinically)
➤ 5–10 mg TID (titrate)
Gabapentin = 𝗔𝗹𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝘃𝗲 / 𝗘𝗾𝘂𝗮𝗹 𝗳𝗶𝗿𝘀𝘁-𝗹𝗶𝗻𝗲
➤ Especially useful in central/idiopathic cases
𝗔𝗹𝘁𝗲𝗿𝗻𝗮𝘁𝗶𝘃𝗲𝘀
Metoclopramide = 𝗨𝘀𝗲𝗳𝘂𝗹 𝗶𝗳 𝗚𝗘𝗥𝗗
➤ 10 mg PO / IV
Haloperidol
Pregabalin
𝗦𝗲𝗰𝗼𝗻𝗱 / 𝗧𝗵𝗶𝗿𝗱 𝗟𝗶𝗻𝗲 (𝗟𝗶𝗺𝗶𝘁𝗲𝗱 𝗘𝘃𝗶𝗱𝗲𝗻𝗰𝗲)
➤ Valproate
➤ Nifedipine
𝗦𝗶𝗺𝗽𝗹𝗲 𝗕𝗲𝗱𝘀𝗶𝗱𝗲 𝗠𝗲𝗮𝘀𝘂𝗿𝗲𝘀
➤ Breath holding / Valsalva
➤ Drinking cold water
➤ Swallowing sugar
➤ Avoid large meals, alcohol
Short-duration hiccups (