05/28/2026
A clinical study investigated whether the herb Rhodiola rosea could help reduce symptoms of mild-to-moderate depression compared to the antidepressant sertraline (Zoloft) and placebo.
The Study
Researchers conducted a 12-week randomized, double-blind, placebo-controlled trial involving adults with mild-to-moderate major depressive disorder. Participants received either Rhodiola rosea extract, sertraline, or placebo, and depressive symptoms were monitored throughout the study.
Key Findings
After 12 weeks, researchers observed:
🔹 Both Rhodiola and sertraline were associated with reductions in depressive symptoms
🔹 Sertraline showed greater symptom improvement overall
🔹 Rhodiola was better tolerated and associated with fewer reported side effects
These findings suggest that Rhodiola may offer modest mood-supportive effects with a more favorable side-effect profile.
Study Limitations
While promising, this research also has several limitations:
🔹 Small sample size
🔹 Mild-to-moderate depression only
🔹 Neither treatment significantly outperformed placebo statistically
The Takeaway
This study suggests that Rhodiola may help support mood in some adults with mild-to-moderate depression and may be associated with fewer side effects than sertraline. However, larger clinical trials are still needed to better understand its effectiveness and long-term role in mental health support.
PMID: 25837277
Informational only. Not medical advice.
