EDS Zebra Articles

05/26/2026

2026 Too high and too loose: dysautonomia and the hypertensive paradox in hypermobility disorders

Management of hypertension in hEDS/HSD requires adaptation of standard guidelines to accommodate dysautonomia-specific considerations, including withdrawal of provocative medications, avoidance of volume-depleting agents, and phenotype-directed pharmacotherapy. Long-term cardiovascular outcomes rema...

05/25/2026

2026 Esophageal Dysmotility and Gastroesophageal Reflux Disease Risk in Hypermobile Ehlers-Danlos Syndrome

05/22/2026

2026 Morphological and functional echocardiographic findings in pediatric patients diagnosed with hypermobile Ehlers-Danlos syndrome

IntroductionHypermobile Ehlers-Danlos syndrome (hEDS) is a connective tissue disorder that may involve the cardiovascular system. While mitral valve prolapse...

05/22/2026

2026 Recurrent massive hematoma after trivial trauma in Ehlers–Danlos syndrome: a case report highlighting diagnostic urgency and surgical challenges

Musculocontractural Ehlers–Danlos syndrome (mcEDS) is a rare connective tissue disorder characterized by abnormal collagen structure, tissue fragility, and predisposition to disproportionate hematoma formation following trivial trauma. Large ...

05/22/2026

2026 Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders: A Mentored Review

Gastroenterologists should maintain a high index of suspicion for hEDS/HSD, which can be readily screened for using the Beighton score. Earlier diagnosis may be therapeutic by reducing uncertainty related to multisystem symptoms. A multidisciplinary approach incorporating mental health, nutrition, a...

05/22/2026

2026 Fatal Aortic Rupture at Term Pregnancy Caused by Vascular Ehlers-Danlos Syndrome Diagnosed by Postmortem Genetic Testing Using Formalin-Fixed, Paraffin-Embedded Tissue

Vascular Ehlers–Danlos syndrome (vEDS) is a life-threatening connective tissue disorder that often remains undiagnosed before pregnancy and carries a markedly high risk of maternal mortality. We repo...

05/22/2026

2026 Comprehensive analysis of the skeletal phenotype in Chst14 −/− mice: implications for dermatan sulfate in bone structure and strength

Abstract. Dermatan sulfate (DS) is a glycosaminoglycan known to contribute to tissue strength through collagen fibril assembly. Musculocontractural Ehlers–

05/22/2026

2026 Asymptomatic Pulmonary Involvement as the Initial Presentation of Vascular Ehlers-Danlos Syndrome with a Novel COL3A1 Frameshift Variant: A Case Report

Vascular Ehlers-Danlos syndrome (vEDS), a rare connective tissue disorder caused by pathogenic COL3A1 variants, rarely presents with isolated pulmonar …

05/22/2026

2026 Rare Type 1 Collagen Variants in Early-Onset Bicuspid Aortic Valve Disease: Clinical and Genetic Overlap with Ehlers-Danlos Syndrome and Osteogenesis Imperfecta

Rare variants in type I collagen genes COL1A1 and COL1A2, classically associated with osteogenesis imperfecta and Ehlers–Danlos syndromes, are enriched in early-onset bicuspid aortic valve disease and may accelerate valve or aortic complications. These findings expand the spectrum of COL1-related ...

05/22/2026

2026 Insights in altered eating behaviors in women with Ehlers-Danlos syndromes

Background Recent research on Ehlers-Danlos syndromes (EDS) highlights a high frequency of disordered eating behaviors and Body Mass Index (BMI), especially in the hypermobile subtype. These problems might be secondary to EDS symptoms and comorbidities such as gastrointestinal (GI) problems, food al...