10/23/2026
One of the most confusing lab findings in autoimmune disease is anemia that doesn't seem to make sense.
Your iron intake is fine. You're eating red meat, taking supplements, doing everything right. But the hemoglobin is still low. And the iron studies come back looking strange.
This has a name: anemia of chronic inflammation. And it's one of the most common issues we see in patients with autoimmune disease.
Here's what's actually happening.
𧬠The body is hoarding iron on purpose
When there's inflammation, the immune system releases a cytokine called IL-6. IL-6 tells the liver to make more of a hormone called hepcidin.
Hepcidin is your body's iron traffic controller.
When hepcidin goes up, it does two things:
π Blocks iron absorption from the gut (so the iron in your food doesn't get taken in efficiently)
π Traps iron inside your cells (specifically in macrophages, so it can't be released to make red blood cells)
The result: your body has iron, but it can't use it well. Iron sequestration is one of several ways inflammation suppresses red blood cell production.
β‘ Why the body does this
Believe it or not, this is a defense mechanism.
Bacteria and pathogens need iron to grow. When the body senses inflammation, it hides the iron so invaders can't use it.
The problem is that autoimmune inflammation isn't an infection. There's no invader to starve. But the body doesn't know the difference. So it keeps the iron locked up while your red blood cell counts drop.
π©Έ Why iron supplements often don't fix this
If your iron studies show anemia of inflammation, taking more oral iron often doesn't help much. The gut still won't absorb it well. The iron you already have is trapped.
The real solution is controlling the inflammation. Once the disease activity comes down, hepcidin drops, and iron becomes usable again.
π Link in bio.
β¨ Comment "ME" for the Discovery Call Link