10/07/2026
It’s Breast Cancer Awareness Month — and if you’ve done an at-home DNA kit, here’s one thing worth knowing: the BRCA report most kits give you checks only 44 selected variants out of the thousands of known BRCA1/BRCA2 variants. By 23andMe’s own labeling, those variants don’t represent the majority of BRCA variants in people of most ethnicities (they cover roughly a third of cancer-related BRCA variants in people of African American, European, or Hispanic/Latino descent, and fewer in people of East Asian descent).
That means a negative result doesn’t rule out a hereditary cancer risk — most of the BRCA changes that raise risk in the general population wouldn’t be caught by the kit. The FDA itself cautions that these results shouldn’t guide medical decisions, and that results should be confirmed with clinical testing and genetic counseling before acting on them.
And BRCA1 and BRCA2 aren’t the whole story. Other genes — like PALB2, CHEK2, ATM, and TP53 — also raise breast cancer risk, and at-home kits don’t look at any of them. Clinical genetic testing reads the full BRCA1 and BRCA2 genes (plus dozens of other cancer-risk genes), checks for larger missing or duplicated pieces, and — the part a kit can’t do — a genetic counselor explains what your results actually mean for you and your relatives.
If your family history raised questions the kit didn’t answer, let’s talk.
Link in bio — telehealth appointments available.