06/03/2026
I don’t think it’s possible to prevent 100% of muscle loss. Nor do I think that should be the goal. It’s OK to lose some muscle when the overall body mass has decreased. You need less mass when you’re moving less mass.
What’s not OK is to lose functional status the goal with weight loss is to improve your function. To have less difficulty sleeping, toileting, playing with your kids, performing your work, etc.
What’s more concerning to me is when someone is entirely sedentary, takes a GLP one, loses 80 to 100 pounds, and then can no longer pick up their toddler or grandchild. That’s devastating. But to have a little bit of muscle loss or a slight decrease in your one rep maximum at the gym isn’t a big deal in my opinion.
Many of the studies are also showing muscle QUALITY improves with weight loss. The MRI scans are showing less fat deposits within the muscle. That’s a very good thing but still reads as “muscle loss” on the DEXA.
Hope this helps.