06/18/2026
Do you feel wired but tired?
You may have heard of the COMT gene, but what happens when your body breaks down dopamine, norepinephrine, and catechol estrogens more slowly than normal?
Individuals with a slow COMT variant may be more prone to:
- Anxiety and stress sensitivity
- Racing thoughts and sleep disturbances
- Caffeine intolerance
- Hormonal imbalances
- Mood swings and irritability
- Feeling overwhelmed under stress
The good news? Your genetics are not your destiny.
Understanding how your body processes neurotransmitters can help you make more informed decisions about nutrition, supplementation, lifestyle habits, and environmental exposures that support overall wellness.
Swipe through to learn:
Common signs of slow COMT
Foods and habits that may help support balance
Supplement considerations
What to avoid if you’re sensitive to methyl donors
Have you ever noticed that caffeine, stress, or certain supplements affect you differently than other people? Let us know in the comments.