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Project ALS Project ALS is finding and funding a cure for ALS. Learn more at projectals.org.
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10/19/2026

Seven years ago, Jaci Hermstad became the first person in the world to receive jacifusen, an experimental treatment developed in the race to save her life.

What began as an effort to help one young woman has since grown into something much bigger.

In September 2026, Otsuka announced that the Phase 3 FUSION trial for ulefnersen, formerly known as jacifusen, met its primary endpoint.

From Alex Hermstad, twin sister of Jaci, whose donated tissue helped begin this research, to Jaci, whose treatment helped pave the way forward, the Hermstad sisters' legacy continues to shape the future of ALS research.

Read the full release here: https://bit.ly/3VYwy35

It's time for some weekend ALS trivia! 🧠True or False: Approximately 90% of people diagnosed with ALS have no clear inhe...
10/18/2026

It's time for some weekend ALS trivia! 🧠

True or False: Approximately 90% of people diagnosed with ALS have no clear inherited genetic cause. Think you know the answer? Swipe to find out!

Want to help move the science forward? Explore the many ways you can support ALS research at https://bit.ly/4yprz91. 🔬

10/15/2026

Meet Annelise and Olivia. Two sisters who are running in honor of their father, who lost his life to ALS. 👭🏻

This November, the sisters will take to the streets as part of Team Project ALS at this year’s TCS New York City Marathon. For Annelise and Olivia, each mile is an opportunity to honor their father's life and carry his memory forward while supporting ALS research.

Show Annelise and Olivia some love and support their marathon fundraising efforts: https://bit.ly/4dDiF0j

Motor neurons are nerve cells that carry messages from your brain and spinal cord to your muscles, telling them to move....
10/14/2026

Motor neurons are nerve cells that carry messages from your brain and spinal cord to your muscles, telling them to move.

Every time you walk, speak, swallow, pick up a coffee cup, or take a breath, motor neurons are at work.

In ALS, these cells progressively become damaged and die. Without the signals they send, muscles weaken and eventually lose their ability to function.

When Project ALS founder Jenifer Estess was diagnosed with ALS at 35, she asked a simple but ambitious question:

“If we can replace damaged hearts and lungs, why can’t we replace dying motor neurons?”

That question launched Project ALS.

We set out to understand exactly what happens to motor neurons in ALS, why they die, how we might protect them, and ultimately, whether we could repair or replace them.

Today, Project ALS researchers grow human motor neurons in the lab, including neurons made from cells donated by people living with ALS. We use them to study disease, identify potential treatments, and explore ways to protect, repair, and rejuvenate these critical cells.

More than 28 years later, Jenifer’s question still drives us:

How do we keep motor neurons alive, and how can what we learn lead us to the first effective treatments for ALS?

“Through this collaboration, the community she built is helping shape research.”In our latest blog, Project ALS Executiv...
10/14/2026

“Through this collaboration, the community she built is helping shape research.”

In our latest blog, Project ALS Executive Director Margot Shanahan shares how 27 women living with ALS are helping advance research inspired by Her ALS Story founder Leah Stavenhagen.

Read the blog to learn how Leah's legacy continues to shape ALS research and inspire the community she built: https://bit.ly/4B4xnrf ♥️

The Project ALS Therapeutics Core, also known as the Core, started eight years ago as a focused effort to translate basi...
10/12/2026

The Project ALS Therapeutics Core, also known as the Core, started eight years ago as a focused effort to translate basic ALS research into new therapies and clinical tools for ALS.

The Core is not a building, but an extensive, open-campus collaboration among academic labs, industry partners, and the ALS community. Five years ago the Core developed prosetin, its first new ALS drug candidate, and passed it to industry partners for clinical development.

Today, the Core is optimizing additional therapies, from ASOs to small molecule compounds, for their proven safety and efficacy in patient-specific models of ALS. That’s a lot of words to say: The goal of the Core is to develop new, safe, and effective ALS diagnostics and drugs. Pre-clinical research is our specialty! We develop and de-risk new therapies and tools, optimizing outcomes for people living with ALS.

Learn more about the Core here: https://bit.ly/47NYOIh

ALS needs the best minds, wherever they begin. At Project ALS we don’t just look for the best ALS researchers. We look f...
10/09/2026

ALS needs the best minds, wherever they begin.

At Project ALS we don’t just look for the best ALS researchers. We look for the best researchers, period.

For nearly three decades, we’ve actively recruited scientists from outside the traditional ALS field, bringing new expertise, technologies, and ways of thinking to the problems ALS research needs to solve.

Dr. Elizabeth Engle studies the motor neurons that control eye movement, neurons that are remarkably resistant to ALS. We brought her expertise into ALS to ask: What can the motor neurons ALS spares teach us about protecting the ones it attacks?

Dr. Talmo Pereira pioneered the use of AI to capture and analyze movement from video. We brought his expertise into ALS to ask: Can AI detect changes in movement that humans can’t see, helping us recognize ALS earlier and measure disease more precisely?

Dr. Ai Yamamoto studies how brain cells identify and clear damaged or abnormal proteins. We recruited her to ask: Why can't ALS motor neurons clear these harmful proteins, and could correcting defects in the cellular recycling system help motor neurons survive?

Different fields. Different expertise. One very difficult problem.

Sometimes the person with the next great insight into ALS hasn’t spent their career studying ALS.

Our job is to find them, bring them into ALS, and give them the resources to get to work.

Happy DAF Day! What will your DAF do?🎉🧡A Donor-Advised Fund (DAF) is more than a way to give. It’s an opportunity to tur...
10/08/2026

Happy DAF Day! What will your DAF do?🎉🧡

A Donor-Advised Fund (DAF) is more than a way to give. It’s an opportunity to turn your charitable dollars into meaningful impact. By recommending a grant to Project ALS through your DAF, you can help fuel innovative ALS research.

This DAF Day, we would appreciate it if you put your generosity to work for science! 🔬
Learn how to support Project ALS through your Donor-Advised Fund: https://bit.ly/4jGcc8A

10/07/2026

Meet Andrew. He’s no stranger to going the distance for ALS. After taking on the Los Angeles Marathon with , Andrew is back for another marathon, this time through the streets of New York City.

He is running in honor of his brother, Joey, who is living with ALS. Every mile is personal, and every step reflects his commitment to supporting the research working toward a cure.

Support Andrew as he races forward and advances ALS research. Donate to Andrew’s run: https://bit.ly/3UbWOqc 📢

This week we celebrate DAF Day! A donor-advised fund can make giving to charity simpler, more purposeful, and more effec...
10/05/2026

This week we celebrate DAF Day!

A donor-advised fund can make giving to charity simpler, more purposeful, and more effective. If you already have a DAF or are thinking of setting one up, the money you donate can be used to support ALS research, which is helping us get closer to effective treatments and eventually a cure.

This DAF Day, put your giving to work for ALS research. Learn more about donor-advised giving and recommend a grant to Project ALS: projectals.org/dafgiving

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