06/17/2026
One of the things I continue to learn as I expand my knowledge in women's health, hormones, metabolism, and mental health is how interconnected our bodies truly are.
Many of us have heard, or even said, "Your labs look fine." I know I have. Looking back, I realize that sometimes standard lab work doesn't tell the whole story. As clinicians, we have so much to consider when evaluating symptoms, and ongoing education helps us provide better care for our patients.
One tool that has gained attention in both research and clinical practice is the HOMA-IR (Homeostatic Model Assessment of Insulin Resistance). HOMA-IR is a calculation that uses fasting glucose and fasting insulin levels to estimate how hard the body is working to maintain normal blood sugar levels.
Why does this matter?
Insulin resistance can develop years before someone meets the criteria for prediabetes or diabetes. During this time, blood sugar levels may still appear "normal" on routine testing, while the body is producing increasing amounts of insulin to keep glucose controlled.
Research has linked insulin resistance to:
• Weight gain and difficulty losing weight
• Fatigue and brain fog
• Cravings and increased hunger
• PCOS and fertility concerns
• Inflammation
• Cardiovascular disease risk
• Hormonal imbalances
• Anxiety, depression, and cognitive changes
HOMA-IR helps identify metabolic dysfunction earlier, allowing for conversations about nutrition, movement, sleep, stress management, and other interventions before blood sugar abnormalities become obvious.
This is one reason I continue to appreciate a more comprehensive approach to health. Hormones affect mood. Metabolism affects hormones. Sleep affects both. Mental health and physical health cannot be separated.
If you've ever been told your labs are normal but you still don't feel well, it may be worth taking a deeper look. Sometimes the answers are found in the patterns between labs, symptoms, lifestyle factors, and physiology rather than a single "abnormal" result.
The more I learn, the more I realize how much there is to learn. My goal at Jubilee Wellness Collective is to continue growing, asking better questions, and providing evidence-based, compassionate care that looks at the whole person—not just a lab value.