08/25/2026
🚩🚩🚩 New nystagmus that suppresses in the DARK and is visible in the LIGHT? Major red flag for possible/likely central (brain) pathology!
📚❤️🩹 A 36-year-old male presented with sudden-onset vertical diplopia (double vision), dizziness, and slurred speech. He had a history of arrhythmogenic right ventricular dysplasia (rare genetic heart condition).
🕵️🧩 Findings on exam:
Infrared video goggles showed hemi-seesaw nystagmus (HSSN) with visual fixation (LIGHT), consisting of intorsional upbeat nystagmus in the right eye occurring synchronously with extorsional downbeat nystagmus in the left eye (counterclockwise from the patient’s perspective). This nystagmus suppressed in the DARK.
Bilateral upward gaze palsy with partial impairment of downward gaze (oculomotor sign).
Vertical saccades and smooth pursuit were impaired due to the vertical gaze palsy.
The horizontal canals were normal per video head impulse test, making peripheral vestibulopathy unlikely.
🧠🚩 MRI brain revealed acute infarction in the left medial thalamus and upper midbrain.
🏆✅ This case example is from an excellent paper by Kim et al. (2023) entitled “Visual Fixation-Induced Hemi-Seesaw Nystagmus,” so I’d like to give full credit to those researchers for this helpful video learning opportunity.
🤔⛔ Important lesson: Don’t assume a 36-year-old can’t have a stroke! If new central signs are present, it’s time for MRI brain imaging and other relevant tests (MRA, etc.) as appropriate.
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