10/03/2026
If you’re in your 40s and suddenly feeling like you can’t remember anything, you’re not alone. It’s a very common symptom of perimenopause. Here’s why:
Estrogen receptors are found throughout the brain, including in regions responsible for memory, verbal fluency, and executive function.
Estrogen also supports the production of acetylcholine, which is a neurotransmitter central to memory and learning.
When estrogen levels fluctuate and decline during perimenopause, these systems are all affected.
The brain fog, word-finding difficulties, and memory lapses that many women in their 40s experience are the brain adapting to a new hormonal environment.
The good news? For the vast majority of women, this is a feature of the menopause transition, and not a sign of permanent cognitive change.
If you are experiencing this kind of brain fog or any other perimenopause symptoms, it’s worth talking with a clinician trained in menopause. Click the link in our bio to learn more.
*This content is for informational purposes only and is not medical advice. Individual results may vary.