AISA Therapeutics - Anti-Inflammatory Senescence Actives (2026)

06/03/2026

CONTROLLING INFLAMMATION: A FUNDAMENTAL PILLAR OF MODERN LONGEVITY
�Longevity is no longer just about living longer. It is about living better, longer, with functional tissues and preserved organ biology.�Today, global research is converging on a key point:
�👉 low-grade chronic inflammation is one of the main accelerators of aging.�This silent inflammation impacts:�• mitochondrial function�• tissue regeneration�• healing�• vascular and cellular homeostasis,
and on the tangible side, skin quality�• functional capacity, sleep quality, resilience��In aesthetic and regenerative medicine, controlling inflammation is no longer a minor detail: it is a strategy for longevity.�✔ Preserve repair capacity�✔ Avoid cellular exhaustion�✔ Improve response to treatments�✔ Slow down biological aging

02/03/2026

CHRONIC INFLAMMATION: THE SILENT ENEMY OF LONGEVITY

�Current global research converges on the same conclusion: aging is closely linked to a phenomenon called “inflammaging” — chronic, low-grade, persistent inflammation.�Invisible. Silent. Progressive.

�This inflammation:�• alters fibroblasts�• as well as endothelail cells, accelerates collagen degradation�• disrupts cellular communication�• promotes oxidative stress�• weakens connective tissues electron traficking ��

Controlling inflammation means:
�✔ slowing down cellular aging
�✔ preserving the extracellular matrix�
✔ maintaining a better tissue quality�
✔ improving the endogenous repair capacity�In aesthetic medicine, as in preventive medicine, the question is no longer just “correcting,” but modulating the inflammatory environment.��Modern longevity is not based solely on stimulation of restoration. It is based on balance.��

09/02/2026

ORGANIZATION, SAFETY, AND PATIENT EXPERIENCE
�Inflammation as an indicator of management maturity in cosmetic surgery.
�Perioperative inflammatory reactions reflect the level of organization within an aesthetic medicine practice or clinic.�Beyond symptomatic treatment, a modern approach aims to:�
👉 anticipate the inflammatory response�
👉 standardize preparation and recovery protocols�
👉 coordinate teams around common biological objectives�
👉 improve the clarity of the patient’s journey
�The AISA Care approach is part of this healthcare ecosystem, where surgery, medical follow-up, tissue support, and patient care form a continuum rather than a series of separate acts.
�In a context of increasingly informed and demanding patients, the ability to explain, measure, and manage the inflammatory response is also becoming a marker of scientific credibility and professional differentiation.
�Structuring the invisible is often what makes the result visible. https://aisa-care.webflow.io/

07/02/2026

INFLAMMATION & QUALITY OF SURGICAL RESULTS

Controlling inflammation: a major determinant of aesthetic results

In cosmetic surgery, the technical procedure is only part of the equation. The quality of the final result also depends on the tissue's inflammatory response following the procedure.

Poorly controlled inflammation can compromise:

👉 the speed of healing

👉 excessive neovascularization

👉 collagen re-organization

👉 the coherence and final texture of the tissue

The AISA Care approach is part of an integrated peri-operative strategy, where tissue preparation, biological support, and post-operative care become all aspects to integrate into the clinical leverage.

By structuring protocols that take into account the patient's inflammatory terrain—nutritional, metabolic, cutaneous, and microvascular issues—it becomes possible to optimize not only comfort, but also the durability and aesthetic quality of the expected result.

Controlling inflammation is not a minor detail. It is a strategic clinical

tool.

https://aisa-care.webflow.io/

30/01/2026

AISA MOLECULUM: A MOLECULAR APPROACH TO SUPPORTING PRACTITIONERS

▪️ AISA (Anti-Inflammatory Senescence Actives) molecules are bioactive compounds identified for their anti-inflammatory properties and ability to modulate cellular responses in contexts of tissue stress.

▪️Preclinical research behind these extracts shows that they interact with key markers of silent inflammation (efficiently inhibiting interleukin-6 inhibition), while modulating certain levels of cellular stress occuring during the inflammatory response.

▪️This work is part of an evidence-based approach aimed at providing scientifically characterized solutions for medical unmet needs, by exploring new avenues of phyto chemistry..

For surgical practitioners, this opens up several opportunities:

✔️ Supporting perioperative inflammatory modulation

✔️ Promoting a microenvironment conducive to healing

✔️ Supporting recovery while respecting tissue physiology

The important thing is not to “suppress inflammation,” but to optimize the balance between the necessary inflammatory phase and the transition to effective repair phases. In perioperative care, this can translate into better management of postoperative symptoms, reduced discomfort, and potentially better tissue repair quality.

See More fro

m www.aisa-tx.com

27/01/2026

CONTROLLING PERIOPERATIVE INFLAMMATION: A MAJOR CLINICAL CHALLENGE

▪️ In any surgical procedure, whether reconstructive, cosmetic, or functional, managing perioperative tissue inflammation is crucial to optimizing the biological response, limiting complications, and speeding up recovery.

▪️Inflammation is not just a visible clinical sign (redness, swelling, pain). It is a complex biological cascade involving pro-inflammatory cytokines, immune cells, and tissue repair processes. This initial phase is necessary—but if it becomes excessive or prolonged, it can delay healing, increase postoperative pain, and promote unwanted adhesions or fibrosis.

▪️In this context, beyond conventional strategies (local cooling, NSAIDs with their limitations, etc.), the integration of molecules with specific anti-inflammatory activity takes on a strategic dimension. Be a phitochemistry enthousiast and explore new avenues.

Fine modulation of inflammation—without excessive suppression—helps guide the tissue toward a harmonious repair response by supporting the proliferation and remodeling phases.

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19/01/2026

SCIENTIFIC PERSPECTIVE & TISSUE RECOVERY

🔬 Towards a “bio-informed” approach to post-operative care in cosmetic surgery

The post-operative phase is not just mechanical or scar-related:

it corresponds to a series of subtle biological stages:

• initial inflammatory cascade

• oxidative response

• tissue remodeling

scar formation

• matrix stabilization

Several recent publications highlight the benefits of:

✔️ limiting excessive inflammation

✔️ reducing free radical production

✔️ protecting tissues from cellular stress

✔️ preserving mitochondrial energy during the repair phase

In this context, AISA moleculum soft gel Capsules with its monoterpenoid formulation acting as a biologic but wothoit toxicity, are attracting growing interest for their capacoty to control inflammation and cell protection profile. Long validated, published and patented data are suggesting:

🔹 modulation of the inflammatory response, via the inhibition of the pro-inflmmatory cytokines

🔹 an important impact on tissue discomfort, tension and itching

🔹 great consistency of results in pathological, as in not pathological profiles

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17/01/2026

PERIOPERATIVE APPROACH & INFLAMMATION MODULATION

Cosmetic surgery & inflammation control: why should we pay more attention to this?

Beyond the surgical technique, the quality of the results also depends on the inflammatory status and oxidativeof the tissues.

In recent years, several studies in cell biology and tissue physiology have highlighted the importance of addressing:

✔️ oxidative stress induced by surgery

✔️ the balance of the second inflammatory phase, source of fibrosis

✔️ the protection of membranes and mitochondria

✔️ functional tissue recovery

In this context, some researchers are integrationg anti-inflammatory supplements formulated to:

• support endogenous antioxidant systems

• limit the amount of pro-inflammatory cytokines due to existing silent inflammation

• promote a more “pro-recovery” tissue environment

👉 AISA moleculum Capsules are part of this approach to the rational modulation of the inflammatory response, with formulations focused on cell protection and redox balance.

See More from www.aisa-tx.com

06/01/2026

POST-SURGICAL INFLAMMATION: A KEY FACTOR IN THE QUALITY OF THE RESULT AND THUS THE QUALITY OF LIFE OF THE PATIENT

Your goal: reduce complications and enhance the final result. An often underestimated lever is the control of post-operative local reaction, supported by systemic inflammation.

After cosmetic surgery, the inflammatory cascade can:

✔trigger prolonged tissue tension, -

✔delay a refined repair of the skin and underlying structures,

✔amplify feelings of pain or discomfort.

Beyond conventional protocols (ice, appropriate mobilization, standard anti-inflammatory drugs, etc.), surgeons may consider a complementary approach, which has been shown to reduce circulating inflammatory markers (e.g., IL-6, Il-1, TNF-α).

AISA moleculum capsules, based on anti-inflammatory and anti-stress biomolecules, acts on:

➖ the reduction of pro-inflammatory cytokines,

➖ the support of a coherent intestinal barrier,

➖ the balance of the microbiota, contributing to overall immune homeostasis.

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04/01/2026

WHY CONTROLLING POST-OPERATIVE INFLAMMATION MAKES ALL THE DIFFERENCE

💬 In case you are a cosmetic surgeon, optimizing your patients' recovery begins even before visible healing.

Inflammation after surgery is a normal physiological response. But when it becomes excessive or prolonged, it:

✔ delays healing,

✔continuing to act during the second phase of cicatrisation,

✔ increasing swelling and redness,

✔ and possibly altering the desired aesthetic result.

👉 In practice, we know that managing inflammation is not limited to conventional care and pain relief: a systemic approach can complement the care pathway.

📌 This is where AISA moleculum can be added to your protocols as a supplement: the anti-inflammatory supplement, containing natural biomolecules, identified and studied for their anti-inflammatory properties specifically, aims to reduce pro-inflammatory cytokines in the systemic circulation as well in tissues, while repairing gut barrier, contributing to intestinal balance, which helps to reduce overall inflammation.

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24/12/2025

During this festive season, AISA Therapeutics would like to express its sincere gratitude to its customers and partners.

Thank you for your trust, your commitment, and the demanding collaborations we are building together in the service of therapeutic innovation and the healthcare of tomorrow.

May this Christmas be a time of light, rest, and sharing, and may the coming year allow us to continue moving forward together with purpose, rigor, and ambition.

🎄 We wish you and your loved ones a very happy holiday season.

23/12/2025

AISA MOLECULUM FROM MOLECULAR MECHANISM TO CLINICAL IMPACT IN AESTHETIC PRACTICE

Did you know that many signs of skin aging are not only observable, but deeply linked to inflammatory imbalance and chronic physiological stress?

This is where AISA moleculum comes in.

The patented molecule AISA 5203-L—a monoterpene derived from bio-guided selection of natural sources—has been shown in vitro and in vivo to:

✅ Inhibit the expression of pro-inflammatory endothelial adhesion molecules (key markers of tissue inflammation), as well as the transcription factor NF-κB thus also stopping their neo-synthesis;

✅ moderate physiological stress responses, contributing to improved cellular resistance to aging.

In practice:

✔️ Reduction of “silent” inflammation associated with aging

✔️ Improvement in skin immune resistance to aging

✔️ Potential to support the results of procedures (injections, lasers, peels, etc.) by acting beyond the surface

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AISA Therapeutics - Anti-Inflammatory Senescence Actives

06/03/2026

02/03/2026

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