28/08/2026
Oregano (O. onites) essential oil demonstrated liver protective activity in laboratory research. The oil regulated the expression of 32 out of 84 genes related to hepatotoxicity at least 2-fold or more—elevating the expression of 17 genes and diminishing the expression of 15 genes. Its main constituent, carvacrol, was also liver protective but modified the expression of fewer genes (16).
The finding suggests that oregano oil may protect the liver not through a single mechanism, but by influencing a broad network of genes involved in hepatic health. The results also offer a compelling reminder that the biological activity of an essential oil cannot always be reduced to the actions of its most abundant constituent.
https://pubmed.ncbi.nlm.nih.gov/38992651/