12/05/2026
ITB syndrome is now understood as irritation of a highly sensitive fat pad beneath the ITB, rather than just a simple ‘friction’ problem.
The cornerstone of treatment for ITB syndrome, particularly for runners, includes load management, gait retraining, and progressive hip and pelvic strength work.
But occasionally symptoms remain highly irritable or fail to progress despite good rehab.
If imaging (ultrasound/MRI) shows localised inflammation or fluid deep to the ITB, targeted injections can be considered to help settle the pain and allow rehab to move forward.
Here are some injections that might be considered for treatment:
💉 Corticosteroid (cortisone) injections 💉
Cortisone is a potent anti-inflammatory and can provide rapid short-term pain relief, particularly when symptoms are limited to walking or running.
🔷 Injected beneath the ITB (not into it) at the painful interface
🔷 Can quickly reduce local irritation
🔷 Often used to create a ‘window’ for rehab
It’s important to note that cortisone doesn’t address the underlying cause (load and biomechanics), so rehab remains essential.
As practitioners we are usually reserved about prescribing multiple cortisone injections, to avoid long-term tissue damage.
💉 PRP (platelet-rich plasma) 💉
PRP is sometimes used with the aim of modulating inflammation and supporting tissue healing.
🔷 Evidence for PRP in ITB syndrome is limited
🔷 Its use is largely extrapolated from tendinopathy research
🔷 Outcomes appear variable and less predictable
In practice, PRP is typically reserved for chronic, persistent cases that haven’t responded to standard care. They can, however, be performed multiple times without detrimental effects.
Injections can be useful tools for treating ITB syndrome, but they are adjuncts, not solutions for long-term recovery.