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MTHFR Support Global MTHFR Support Australia was created to provide support & raise awareness about MTHFR gene mutations & methylation. http://www.mthfrsupport.com.au

About MTHFR Support Australia:

Why did we decide to focus on MTHFR? Well we started to see more and more chronically ill people who had been to doctors , specialists and countless naturopaths and were just not getting the results they should have been. Individuals with a MTHFR mutation or disordered methylation are presenting with cardiovascular disease, chronic inflammation, depression, anxiety, Diabetes, autoimmune conditions, ADD/ADHD, Down's Syndrome, recurrent miscarriage and cancer- to name a few! We need to heal at a cellular level and what we now see is that nutritional methyl donors are restoring our patients health because we are breaking down the obstacles to healing and decreasing inflammation. We work with nutrition, co-factors and substrates required to bring the methylation cycle back into balance to reduce symptoms

Our learning always continues and it seems the more we know the more we need to know. We truly believe in a collaborative health care approach. The patient has to come first. We all have to try harder to ensure that sick people get better. We need to think outside the square and all put our heads together to ensure this works. We've seen this every day. We know this works. If you are a practitioner, join our PRACTITIONERS ONLY group: https://www.facebook.com/groups/MTHFRPractitionerMembersGroup

🧬 If MTHFR influences folate metabolism, why is testing not routinely recommended?Because finding a common MTHFR variant...
08/10/2026

🧬 If MTHFR influences folate metabolism, why is testing not routinely recommended?

Because finding a common MTHFR variant does not necessarily tell your practitioner what is happening in your body today.

C677T and A1298C are common genetic variants. Many people carry one or two copies without developing a related health problem or having elevated homocysteine.

In many situations, knowing the genotype would not change the next clinical step.

A practitioner may gain more actionable information by considering:
• Folate status
• Vitamin B12 status
• Homocysteine
• Full blood count
• Kidney and thyroid function
• Diet, medications and symptoms

These results can help show whether there is a current nutritional or metabolic concern that may need attention.

This is also why routine MTHFR testing is generally not recommended as part of an investigation into blood clots or recurrent pregnancy loss. Finding a common variant does not prove that it caused the health concern.

That does not mean MTHFR is irrelevant or that your symptoms should be dismissed. It means the result needs to be interpreted within the wider clinical picture.

Your genes can identify a potential vulnerability.

Your current biochemistry helps show whether that vulnerability may be affecting you now.

Were you offered an MTHFR test, or did you need to request one yourself?

🌸 Spring has arrived, and so have the itchy eyes, sneezing, congestion and runny noses.When someone with a pollen allerg...
08/10/2026

🌸 Spring has arrived, and so have the itchy eyes, sneezing, congestion and runny noses.

When someone with a pollen allergy encounters their trigger, immune cells release histamine. Histamine then contributes to many of the symptoms we associate with seasonal allergic rhinitis.

Your body also has several pathways for breaking histamine down.

DAO is especially important within the digestive system and helps process histamine from food. HNMT works inside cells and tissues, while HDC produces histamine.

This does not mean that recurring allergies are simply caused by poor histamine clearance. Pollen exposure, immune activity, medications, gut health and individual differences may all contribute to the wider picture.

Antihistamines can be an appropriate and effective part of allergy management. Some people may need them regularly under professional guidance, so do not stop prescribed or recommended medication because of a social media post.

However, if you struggle every spring, it may be worth speaking with your doctor or pharmacist about your triggers, medication options, and whether allergy testing or a more complete management plan could help.

In this video, Carolyn Ledowsky explores histamine production and clearance, and why managing recurring symptoms may require more than focusing on one pathway alone.

Watch here: https://www.mthfrsupport.info/allergy/allergy-medications

Do your allergy symptoms become noticeably worse during spring?

🌿 Wellness Wednesday: Why can spring make you feel more tired?The days are getting longer, the weather is warming up, an...
07/10/2026

🌿 Wellness Wednesday: Why can spring make you feel more tired?

The days are getting longer, the weather is warming up, and everything around us seems to be waking up.

So why do some people feel more tired rather than more energised?
Spring brings several changes at once. Longer daylight hours can shift sleep and circadian rhythms, warmer temperatures can affect sleep quality, and increased pollen exposure can activate the immune system in people with seasonal allergies.
For some, that can mean more than sneezing and itchy eyes. Seasonal allergies can also bring fatigue, poor concentration, and disrupted sleep.

Histamine is part of this picture. It plays an important role in the immune response, but it also functions as a neurotransmitter and supports wakefulness. When your overall histamine load increases during pollen season, symptoms may become more noticeable, particularly if other factors such as stress, poor sleep, certain foods or hormonal changes are already adding to the load.

This is where individual biochemistry matters. Histamine metabolism relies on several pathways and nutrients, and genetics can influence some of the enzymes involved. Methylation also participates in one of the pathways used to metabolise histamine within cells.

Rather than assuming spring fatigue means you simply need more coffee, look at what else has changed.
🌿 Are seasonal allergies increasing?
😴 Has your sleep changed?
🥦 Are you eating regularly and getting enough key nutrients?
💧 Are you staying hydrated as the weather warms?
🧠 Are brain fog or headaches appearing alongside other allergy symptoms?
Sometimes feeling different with the seasons isn't in your imagination. Your environment changes, and your body has to adapt.

💬 Do you feel more energised when spring arrives, or does it take your body a while to catch up?

🌿 Mindful Monday: why does spring make you want to start again?Have you noticed that the first few warm days of spring c...
04/10/2026

🌿 Mindful Monday: why does spring make you want to start again?

Have you noticed that the first few warm days of spring can suddenly make you want to change things?

You want to open the windows, clear out the wardrobe, get outside more, start walking again, rearrange the house or finally begin something you've been putting off all winter.

There's something about a change of season that can feel like a natural reset. The days are getting longer, there's more light, everything around us is changing, and suddenly change can feel a little easier, too.

Maybe that's why spring has always been associated with new beginnings.
So instead of making a huge list of everything you'd like to improve this season, choose one thing.

What would you genuinely like to begin again this spring?
It doesn't need to be big. Sometimes a change of season is simply a nice reminder that we're allowed to start again too.

💬 What are you looking forward to bringing back into your life this spring?

🌼 Have your headaches, skin reactions, digestive symptoms or sleep problems become more noticeable since spring arrived?...
01/10/2026

🌼 Have your headaches, skin reactions, digestive symptoms or sleep problems become more noticeable since spring arrived?

Pollen exposure can trigger the release of histamine in people with seasonal allergies. If you are already managing several possible triggers, that additional exposure may make your overall symptom load feel harder to tolerate.

Think of it like a bucket. Histamine and other symptom triggers may come from pollen, certain foods, alcohol, stress, hormonal changes, illness and some medications. When several occur together, you may notice that your usual tolerance changes.

This could look like:
• More frequent headaches
• Itching, flushing or unsettled skin
• Increased digestive symptoms
• Poorer sleep
• Foods feeling harder to tolerate
• Feeling more tired or irritable

The histamine bucket is a useful metaphor, but these symptoms are not specific to histamine. They shouldn't automatically be blamed on food, MTHFR, or histamine intolerance.

If spring consistently changes how you feel, tracking your symptoms, food, pollen exposure, and medications may help you identify patterns to discuss with your healthcare practitioner.

💡 If you would like to understand histamine more deeply, our Histamine Resources Bundle brings together practical education and resources to help you explore possible triggers and ways to reduce your overall load.

Find the Histamine Resources Bundle through the link in our bio. Or click on the link below:
🔗 https://www.mthfrsupport.info/products/238237-Histamine-Resources

Have you noticed your usual symptoms changing since spring began?

🔗🔗🔗

🧬 Why can’t an MTHFR result tell you which supplement to take?Because a genetic result shows inherited information, not ...
30/09/2026

🧬 Why can’t an MTHFR result tell you which supplement to take?

Because a genetic result shows inherited information, not your current nutritional needs.

An MTHFR result does not tell us:
• Whether you are deficient in folate
• Whether your vitamin B12 is adequate
• What your homocysteine level is
• How well you absorb nutrients
• Which medications you take
• Whether you are pregnant or planning pregnancy
• How you have responded to supplements previously

It also cannot calculate the correct form or dose of folate for you.

Finding an MTHFR variant does not automatically mean that you need high-dose methylfolate. It does not prove that folic acid is harmful to you, and it does not mean that more supplementation will produce a better result.

The appropriate approach depends on the individual.

A practitioner may consider diet, symptoms, pathology, medications, digestive health, pregnancy status and the reason supplementation is being considered.

Your genes can help generate questions. They cannot prescribe the answer.

Were you given a supplement recommendation based only on your MTHFR result?

🌿 Wellness Wednesday: Are you eating enough different types of fibre?Most of us have heard that we should eat more fibre...
29/09/2026

🌿 Wellness Wednesday: Are you eating enough different types of fibre?

Most of us have heard that we should eat more fibre.

But when it comes to your gut microbiome, variety matters too.

Your gut is home to trillions of microorganisms, and different microbes have different preferences for the fibres and other compounds they use as fuel. This means eating the same few high-fibre foods every day isn't necessarily the same as eating a wide variety of plant foods.

When certain fibres reach the large intestine, gut bacteria ferment them and produce compounds called short-chain fatty acids, including butyrate, acetate and propionate.

These compounds do much more than stay in the gut. They help maintain the intestinal environment and gut barrier, regulate immunity, and support metabolic signalling.

So rather than searching for the perfect fibre supplement or latest gut health superfood, think about diversity across the week.
🥦 Vegetables
🫘 Beans, lentils and chickpeas
🍓 Fruit and berries
🌾 Whole grains
🥜 Nuts and seeds
🌿 Herbs and spices

Try different colours, different plants and different sources of fibre.

This is also an important part of the functional genomics conversation. Our genes don't operate in isolation. Nutrition, lifestyle, the microbiome and the metabolites our gut microbes produce all contribute to the biological environment in which our genes function.

Supporting health isn't always about finding one perfect nutrient. Sometimes it's about giving your body, and your microbes, a little more variety.

💬 How many different plant foods do you think you eat in an average week?

🥬 Can food support folate status if you have an MTHFR variant?Yes.Having a common MTHFR variant does not mean that folat...
28/09/2026

🥬 Can food support folate status if you have an MTHFR variant?

Yes.

Having a common MTHFR variant does not mean that folate rich food becomes useless or that your body cannot process folate.

Food sources of folate include:
• Lentils and beans
• Leafy green vegetables
• Asparagus
• Avocado
• Broccoli
• Citrus fruit
• Peas
• Fortified foods

Your overall folate status is influenced by more than your MTHFR result. Dietary intake, absorption, medications, alcohol consumption, pregnancy, health conditions and other nutrients may all contribute.

Vitamin B12, riboflavin, vitamin B6 and choline also interact with pathways connected to folate and one-carbon metabolism.

This does not mean that food alone will correct every deficiency or health concern. Some people may require further investigation or individual supplementation.

But an MTHFR variant is not a reason to overlook the basics.

Your genes may influence the pathway.

Your daily nutrition still helps create the environment in which that pathway operates.

Which folate rich food appears most often in your meals?

🌿 Mindful Monday: When did you last do just ONE thing?Think about your morning.Did you drink your coffee while checking ...
27/09/2026

🌿 Mindful Monday: When did you last do just ONE thing?

Think about your morning.

Did you drink your coffee while checking your phone? Eat breakfast while answering emails? Listen to a podcast while getting ready? Watch something while eating dinner?

We've become remarkably good at fitting more into every spare moment.

But when was the last time you did something ordinary without adding anything else to it?

Just drank your coffee.

Just ate your lunch.

Just walked somewhere.

Just listened to a song.

Just had a conversation.

Multitasking can feel productive, but our brains aren't necessarily doing several attention demanding things simultaneously. Much of the time, we're rapidly switching our attention from one thing to another.

So today, choose one ordinary thing and give it your full attention.

It doesn't need to be meditation. It doesn't need to take an hour.

Drink your coffee without scrolling. Take a walk without a podcast. Eat lunch without your laptop.

See what you notice when you're actually there.

💬 Can you remember the last thing you did without doing something else at the same time?

🧬 What does “wild type” mean on a genetic report?It does not mean that part of your DNA is wild, dangerous or unpredicta...
24/09/2026

🧬 What does “wild type” mean on a genetic report?

It does not mean that part of your DNA is wild, dangerous or unpredictable.

In genetics, wild type is a traditional term for the commonly expected or reference version at a particular genetic location.

For example, a report examining MTHFR C677T may describe the CC genotype as wild type because it did not identify the T variant at that position.

However, wild type does not mean:
• Your genes are perfect
• You cannot have symptoms
• Your folate metabolism is automatically optimal
• Your homocysteine must be within range
• Other genes or health factors are irrelevant

It only describes the result at the specific location being examined.

Some laboratories now use terms such as reference allele or variant not detected because “wild type” can easily be misunderstood.

A genetic report describes your DNA.

Those descriptions still need to be interpreted alongside your symptoms, health history, nutrition, medications and relevant pathology.

Did the term “wild type” confuse you when you first saw it?

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