MTHFR Support Global

MTHFR Support Global MTHFR Support Australia was created to provide support & raise awareness about MTHFR gene mutations & methylation. http://www.mthfrsupport.com.au

About MTHFR Support Australia:

Why did we decide to focus on MTHFR? Well we started to see more and more chronically ill people who had been to doctors , specialists and countless naturopaths and were just not getting the results they should have been. Individuals with a MTHFR mutation or disordered methylation are presenting with cardiovascular disease, chronic inflammation, depression, anxiety,

Diabetes, autoimmune conditions, ADD/ADHD, Down's Syndrome, recurrent miscarriage and cancer- to name a few! We need to heal at a cellular level and what we now see is that nutritional methyl donors are restoring our patients health because we are breaking down the obstacles to healing and decreasing inflammation. We work with nutrition, co-factors and substrates required to bring the methylation cycle back into balance to reduce symptoms

Our learning always continues and it seems the more we know the more we need to know. We truly believe in a collaborative health care approach. The patient has to come first. We all have to try harder to ensure that sick people get better. We need to think outside the square and all put our heads together to ensure this works. We've seen this every day. We know this works. If you are a practitioner, join our PRACTITIONERS ONLY group: https://www.facebook.com/groups/MTHFRPractitionerMembersGroup

🧠 Can vitamin B12 or folate affect mood even when blood results appear normal? Sometimes, but a single result cannot tel...
03/09/2026

🧠 Can vitamin B12 or folate affect mood even when blood results appear normal? Sometimes, but a single result cannot tell us the whole story.

Total serum B12 measures vitamin B12 circulating in the blood. When the result is borderline or does not match someone’s symptoms, a practitioner may consider active B12, methylmalonic acid and homocysteine alongside the clinical picture.

Homocysteine can provide useful context, but it is not definitive proof of a “cellular deficiency.” It may be influenced by vitamin B12, folate and B6 status, as well as kidney function, thyroid function, medications, age, smoking and genetics.

Symptoms such as low mood, fatigue, brain fog, irritability or tingling may occur with vitamin B12 or folate deficiency, but they are not specific to either nutrient.

This is why practitioners need to consider:
🔬 The actual result, not simply “within range”
🩺 Symptoms and medical history
🥬 Diet and supplementation
💊 Medications and absorption concerns
🧬 Relevant genetics and wider pathology

An MTHFR result cannot diagnose a folate deficiency, and a normal blood result should not automatically dismiss persistent symptoms.

The laboratory range matters. So does the person behind the result.

Want to explore questions like this more deeply?

Join the Functional Genomics Institute and gain access to Ask Caro, our AI learning assistant created to help members explore questions about genetics, methylation, nutrition and personalised health.

Learn more and join through the link in our bio.

⏰ Final chance to join us in SydneyTicket sales close this Thursday evening for our two-day practitioner workshop:How to...
02/09/2026

⏰ Final chance to join us in Sydney

Ticket sales close this Thursday evening for our two-day practitioner workshop:

How to apply functional genomics for effective and personalised mental health care

This beginner-friendly clinical training gives practitioners a clear framework for supporting anxiety, depression, stress and complex mental health presentations.

Led by Carolyn Ledowsky, the workshop will help you understand how genetic susceptibility, biochemical pathways, nutrient status and environmental influences may shape mental health and treatment response.

Across two practical days, you will learn how to:
🧬 Identify key SNPs relevant to mental health
🔬 Interpret genetic testing alongside functional and traditional pathology
🧠 Recognise biochemical blocks influencing complex presentations
🥬 Develop targeted nutritional and clinical approaches
📋 Apply your learning through real case studies
💬 Ask questions during live Q&A sessions

Every ticket also includes presentation slides, SNP reference guides, assessment tools, clinical protocol templates, a case study workbook, healthy gluten-free catering, a CPD certificate and lifetime access to the workshop recordings.

Whether you are new to genomics or ready to bring greater precision to your existing mental health protocols, you will leave with practical tools you can begin applying in clinic.

📅 4 and 5 September 2026
📍 Norths Cammeray, Sydney
🎓 CPD points available
🎥 Lifetime recording access included
🔗https://mentalhealthworkshop.mthfrsupport.com.au/

Ticket sales close Thursday evening.

If you have been considering joining us, this is your final opportunity to secure your place. Book through the link in our bio.

🌿 Wellness Wednesday: B vitaminsWe hear a lot about B vitamins for “energy”, but their role in the body goes much furthe...
01/09/2026

🌿 Wellness Wednesday: B vitamins

We hear a lot about B vitamins for “energy”, but their role in the body goes much further than that.

There are eight B vitamins, and they work together as cofactors in hundreds of biochemical reactions. They help convert the food we eat into usable cellular energy, produce red blood cells, support the nervous system and synthesise DNA.

🧬 For the MTHFR community, some B vitamins are particularly important.

Folate, B12, B6 and riboflavin all participate in pathways involved in one carbon metabolism and homocysteine regulation. Riboflavin, or B2, is especially interesting because the MTHFR enzyme requires its active form, FAD, as a cofactor.

B vitamins also have important roles beyond methylation:

🔋 B1, B2, B3 and B5 help support cellular energy metabolism.

🧠 B6 is involved in the synthesis of neurotransmitters including serotonin, dopamine and GABA.

❤️ Folate, B6 and B12 contribute to healthy red blood cell formation and homocysteine metabolism.

🧬 Folate and B12 are essential for normal DNA synthesis and cell division.

Most B vitamins are water soluble, so regular dietary intake is important. Good sources include legumes, whole grains, nuts, seeds, leafy greens and fortified foods. Vitamin B12 deserves particular attention for people following plant-based diets because reliable natural plant sources are limited, making fortified foods or supplementation important.

And when it comes to MTHFR, more is not automatically better. Your genetics are only one part of the picture. Diet, blood results, medications, absorption and individual requirements should all be considered before reaching for high dose B supplements.

✨ Supporting methylation is about providing the right cofactors, not simply taking as much methylfolate as possible.

💬 Which B vitamin would you like us to explain in more detail next?

🧬 How can two people with the same MTHFR variant have completely different mental health experiences?Because a genetic v...
31/08/2026

🧬 How can two people with the same MTHFR variant have completely different mental health experiences?

Because a genetic variant does not act alone.

Common MTHFR variants can influence folate metabolism, but they cannot predict whether someone will experience anxiety, depression or another mental health condition.

Two people with the same result may have very different:
🥬 Folate and B vitamin status
🧠 Stress and trauma histories
💤 Sleep quality
💊 Medications
🩺 Hormonal and physical health
🧬 Variants in other genes
🌿 Diet and lifestyle factors

Even their homocysteine levels may differ completely.

COMT and other genes may add further context, but one combination of variants cannot tell us that neurotransmitters are accumulating or explain someone’s symptoms on its own.

The variant may be the same. The person’s biology, experiences and environment are not.

This is why personalised mental health care must look beyond one SNP.

🔬 Explore the wider picture at Functional Genomics For Effective & Personalised Mental Health Care, led by Dr Carolyn Ledowsky.

📅 4 and 5 September
📍 Sydney
🎓 Eight practitioner sessions
🧬 Live case studies
💬 Q&A with Dr Carolyn Ledowsky and Dr Nathan Francis
🤝 Networking and workshop recording included
💳 Payment plans available

Book through the link in our bio.

🌿 Mindful Monday: why does doing nothing feel so uncomfortable?You finally get a moment where nobody needs anything from...
30/08/2026

🌿 Mindful Monday: why does doing nothing feel so uncomfortable?

You finally get a moment where nobody needs anything from you. There's nothing urgent to do, and nowhere you need to be.

So what happens?

You pick up your phone. Check your emails. Put on a podcast. Suddenly remember the washing. Maybe you even start cleaning something that absolutely did not need cleaning.

Doing nothing can feel surprisingly uncomfortable.

Part of the reason may simply be that we've become very good at filling every empty moment. Our brains are rarely left without something to process, whether it's work, messages, news, entertainment or the endless stream of information on our phones.

And when that stimulation disappears, the quiet can feel unfamiliar.

So here's a little experiment for today. The next time you have five minutes with nothing to do, don't fill them immediately.

No scrolling. No podcast. No productive little task.

Just notice what happens.

Do you feel relaxed? Restless? Bored? Do you immediately start thinking about what you *should* be doing?

You don't have to change anything. Just notice it.

After all, that's what mindfulness is really about. 🌿

💬 How good are you at doing absolutely nothing?

🧬 Can MTHFR cause anxiety?The connection is more complicated than a yes-or-no answer.MTHFR variants can influence folate...
27/08/2026

🧬 Can MTHFR cause anxiety?

The connection is more complicated than a yes-or-no answer.

MTHFR variants can influence folate metabolism, which supports processes that contribute to brain health. However, an MTHFR result cannot prove that someone’s anxiety is caused by impaired methylation, depleted neurotransmitters or poor COMT function.

Anxiety can be influenced by stress, trauma, sleep, hormones, medications, nutrient status, thyroid function, physical health and many other genetic and environmental factors.

Elevated homocysteine may provide another clue, but it is not proof that MTHFR is driving someone’s anxiety. Interpret it alongside folate, vitamin B12 and B6 status, kidney and thyroid function, medications, diet, and the wider clinical picture.

Your genes may provide context. They do not replace a complete mental health assessment.

🔬 Want to explore these connections more deeply?

Join Dr Carolyn Ledowsky for Functional Genomics for Effective & Personalised Mental Health Care, a two-day, in-person practitioner workshop.

📅 4 and 5 September
📍 Sydney
🎓 Eight educational sessions
🧬 Live case studies
💬 Q&A with Dr Carolyn Ledowsky and Dr Nathan Francis
🤝 Practitioner networking
🎥 Workshop recording included
💳 Payment plans available
🔗https://mentalhealthworkshop.mthfrsupport.com.au/

Learn how to examine the genetic, biochemical and nutritional factors influencing mental health without interpreting one gene in isolation.

Book through the link in our bio.

🧬 Two MTHFR variants. Does that mean your methylation is functioning at only 50%?Not necessarily.The variants c.665C>T a...
26/08/2026

🧬 Two MTHFR variants. Does that mean your methylation is functioning at only 50%?

Not necessarily.

The variants c.665C>T and c.1286A>C are also commonly reported as C677T and A1298C. When one copy of each variant is present, this is often called compound heterozygous MTHFR.

Older laboratory research found that this combination was associated with approximately 50 to 60% of the measured MTHFR enzyme activity seen in the comparison group.

But this cannot be translated into “your methylation is working at 50%.”

MTHFR is one enzyme within the much larger folate and one carbon metabolism network. Methylation also depends on folate intake, vitamin B12, riboflavin, vitamin B6, choline, kidney and thyroid function, medications, alcohol intake and many other genes and enzymes.

A genetic result also cannot prove that MTHFR is causing anxiety, fibromyalgia, endometriosis, inflammation or fatigue. These are complex conditions with many possible contributing factors.

What can provide more useful clinical context?
🔬 Folate and vitamin B12 status
🔬 Homocysteine
🔬 Full blood count
🔬 Kidney and thyroid function
🔬 Diet, medications and symptoms

A homocysteine result of 13.7 may deserve investigation, depending on the laboratory range and the person’s wider health picture. However, it is not proof that “methylation has failed.” Homocysteine may also be influenced by nutrient deficiencies, kidney function, thyroid function, age, smoking and medications.

Common MTHFR variants may create a potential pressure point within folate metabolism.

They do not provide a percentage score for your entire methylation system, explain every symptom or prescribe a supplement protocol.

Your genes offer context. Your current biochemistry helps show what may actually be happening.

Were you ever given a percentage to describe how well your methylation was functioning?

🌿 Wellness Wednesday: Winter recoveryWe’re getting closer to spring, but your body might not be feeling it just yet.By t...
25/08/2026

🌿 Wellness Wednesday: Winter recovery

We’re getting closer to spring, but your body might not be feeling it just yet.

By the end of winter, it’s quite common to feel a little depleted. We’ve had months of shorter days, less sunlight, more time indoors and, for many people, at least one winter virus thrown into the mix. Add work, stress and everyday life, and it makes sense that energy can feel lower than usual.

Winter can also affect how we feel for physiological reasons. Reduced sunlight can influence circadian rhythm and vitamin D status, while seasonal changes in activity, sleep and diet can affect mood, energy and immune function.

Rather than seeing the arrival of spring as a signal to suddenly “reset”, this can be a good time to focus on rebuilding.

🌿 Get outside when Sydney gives us a break in the rain and expose your eyes to natural morning light.

🥦 Bring more colourful seasonal plants back onto the plate while maintaining adequate protein and key nutrients involved in energy and methylation.

🚶 Gradually increase movement as the days become longer.

😴 Keep prioritising sleep rather than assuming you should suddenly have more energy because winter is ending.

For those with MTHFR polymorphisms, supporting nutrient status remains particularly important, but there is no need for an extreme spring detox. Methylation and normal detoxification processes happen every day and rely on adequate nutrition, sleep and overall metabolic health.

Sometimes the best way to enter a new season isn't with a cleanse or a complete overhaul. It’s simply giving your body a little time to catch up.

💬 Are you ready for spring, or still very much in winter mode?

🧬 When people discuss MTHFR, the conversation usually begins and ends with folate.But another nutrient deserves attentio...
24/08/2026

🧬 When people discuss MTHFR, the conversation usually begins and ends with folate.

But another nutrient deserves attention: vitamin B2, also known as riboflavin.

The MTHFR enzyme needs a riboflavin-derived coenzyme to function. Research suggests that the C677T variant can make the enzyme less stable, particularly in people with the TT genotype.

This means riboflavin status may influence how efficiently the enzyme works. Some research has also found that riboflavin supplementation may help lower homocysteine or blood pressure in certain people with the 677TT genotype.

However, this does not mean that everyone with an MTHFR variant needs a high-dose B2 supplement.

The result still needs to be considered alongside diet, symptoms, folate and vitamin B12 status, homocysteine, medications and the wider clinical picture.

🥬 Vegan sources of riboflavin include almonds, mushrooms, spinach, fortified cereals, soy foods and some fortified nutritional yeast.

MTHFR support is not simply about adding more methylfolate.

Sometimes the nutrient receiving the least attention may be an important part of the picture.

Has anyone ever discussed riboflavin with you after you received your MTHFR result?

🌿 Mindful Monday: small steps, big impactWe tend to notice the big milestones, but most changes in our health don't happ...
24/08/2026

🌿 Mindful Monday: small steps, big impact

We tend to notice the big milestones, but most changes in our health don't happen because of one huge decision. They happen through the small things we do repeatedly.

Going for a ten-minute walk. Adding something nourishing to your lunch. Getting to bed a little earlier. Drinking another glass of water. Taking five minutes outside instead of automatically reaching for your phone.

None of these things feels particularly life-changing in the moment, and that's exactly why we often overlook them.

But you don't need to completely overhaul your life every Monday. Pick one small thing that feels achievable today and start there. 🌿

Small actions become habits, and habits can add up to meaningful change over time.

💬 What's one small thing you're doing for yourself this week?

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