27/08/2026
Not specifically a bone post, but I suspect followers will nevertheless be interested because it is exercise-related. Ever since one illustrious scientist declared "Sitting is the new smoking", there has been lively discussion on just how bad sitting is for us and whether and how much exercise can overcome the negative effects. For a while it appeared that no amount of exercise could overcome the increased risk of mortality from the prolonged daily sitting most of us do, but then one study provided some hope. It showed that the benefit depends on how much sitting and the level of intensity of the exercise. The below plot shows the more energy you put into exercise, the less bad long periods of sitting are for you (left hand end of the plot) but that milder forms of physical activity are unlikely to overcome the effects of sitting, especially the longer you sit (right hand end). (To understand the plot, a hazard ratio of 1 is the baseline - no increased risk. A hazard ratio of 1.1 means a 10% greater risk, and so on.) Distilling down to the practical implications, around 60–75 min of moderate intensity activity per day is probably necessary to receive protective benefit against the risks of prolonged sitting. In science, the devil is always in the detail. (And yes, ONERO is one of those good higher intensity exercises towards the left hand end of the plot, but you need to be doing exercise that makes you puff and sweat a bit [aerobic] on the other 5 days as well.)
https://pubmed.ncbi.nlm.nih.gov/27475271/