03/09/2026
A meta-analysis of randomised controlled trials found that standardized red clover isoflavone extracts may moderately reduce the daily frequency of hot flashes in peri- and postmenopausal women.
Some studies reported significant improvements, particularly with doses of 80 mg or higher, while others showed only small or non-significant effects. Red clover also appeared to lower scores on symptom rating scales such as the Kupperman index, though findings were inconsistent across different measures. Limitations include small sample sizes, variations in isoflavone metabolism between women, and a strong placebo effect commonly seen in hot flash trials.
Overall, red clover shows potential for easing vasomotor symptoms, but more rigorous, well-designed research is needed to clarify optimal doses, duration, and effectiveness for broader menopausal symptoms.
PMID: 33920485
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