10/10/2026
🧠💪 CAN STRONGER MUSCLES HELP PROTECT THE BRAIN DURING CHEMOTHERAPY?
Chemotherapy doesn’t just affect cancer cells. It can also impact skeletal muscle health, physical function and cognitive performance.
Emerging research highlights an important connection between our muscles and brain, known as the muscle–brain axis.
🔬 WHAT DOES THE RESEARCH SUGGEST?
• Skeletal muscle mass may decline by approximately 3–10% during chemotherapy.
• Cognitive impairment can affect up to one-third of patients.
• Muscle dysfunction, inflammation and altered muscle-derived signalling may contribute to changes in brain health.
🏋️ WHERE DOES EXERCISE FIT IN?
Resistance training can help preserve muscle mass, strength and physical function.
Aerobic exercise can support cardiovascular fitness, mitochondrial function and overall health.
Together, these approaches may help support the muscle–brain connection during cancer treatment.
💡 THE TAKEAWAY
Muscle health isn’t just about strength or appearance. It may play an important role in protecting physical and cognitive function during chemotherapy.
While the mechanisms are promising, more research is needed to establish whether preserving muscle directly reduces chemotherapy-related cognitive impairment.
At FORGE ALLIED HEALTH, we believe exercise is more than fitness. It’s an important part of evidence-informed healthcare.
⚕️ Exercise during cancer treatment should be individually prescribed and coordinated with the treating oncology team.
📚 Research: Chemotherapy-Induced Skeletal Muscle Dysfunction and Cognitive Impairment — Journal of Cachexia, Sarcopenia and Muscle (2026).