26/03/2023
Dear All,
I would like to invite you to the CMRP seminar entitled: “Photodynamic therapy in biomedicine” by Prof. David Aebisher, Head of The Department of Photomedicine and Physical Chemistry,
University of Rzeszów, Poland.
The seminar will be on Thursday the 30th of March, at 5:00 pm local time, via Zoom at:
https://uow-au.zoom.us/j/7982381116
Abstract:
David Aebisher research interest and bulk of published works is on the development of devices for the localized delivery of 1O2 for Photodynamic Therapy (PDT). PDT is a treatment that uses a combination of light-absorbing photosensitizers (PS) and dissolved oxygen to kill cancer. As a cancer treatment, PDT therapy is considered to be a more mild approach as oxygen and light are the starting materials and ROS such as 1O2, and to a lesser extent superoxide (·-O2) and hydroxyl radical (·OH), are the active agents responsible for eliciting cancer cell death as opposed to agents which are toxic to the body as a whole such as chemotherapy drugs and radiation. Singlet oxygen is a short lived ROS (< 1 μs in the cell), thus a requirement is to release and deliver 1O2 within distance of ca. 200 nm from targets within a cell. PDT is gaining in popularity among physicians although few laboratory PDT systems have made the transition to clinical use due to limitations such as the tissue penetrating ability of visible light. PDT is also a method that can be controlled with regards to the location of the treatment as it requires selective illumination of the treatment area with light. Selective illumination and light activation then enables selective damage of diseased tissue without damaging the surrounding healthy tissue.
Short biography of the speaker:
David Aebisher was born in New York, USA. He graduated from two majors (mathematics and physiology) at the University of Wyoming (University of Wyoming, Laramie, USA). At the same University (in 2001), under the supervision of Professor Edward Clennan, he obtained his PhD in physical-organic chemistry for the defense of his doctoral thesis entitled Mechanistic Studies on the Sulfide-Singlet Oxygen Reaction Surface. In February 2018, he obtained his habilitation in medical sciences at the Faculty of Medicine with the Faculty of Medicine and Dentistry in Zabrze of the Medical University of Silesia in Poland for the scientific achievement entitled Localized Delivery, Release and Tracking of Highly Reactive Anticancer and Antimicrobial Agents.
He started his scientific career as a Research Assistant at the University of Wyoming, Department of Chemistry (Laramie, Wyoming, USA) where he worked in the years 1994–2001. From 2002 to 2004 he was employed as a Research Associate at the Department of Chemistry of the University of Illinois at Chicago. In 2005–2011 he worked as an Adjunct Assistant Professor at the Department of Chemistry at The City University of New York, Brooklyn College (Brooklyn, New York, USA), and in 2012–2016 he was an assistant professor at Shorter University (Rome, Georgia, USA). For five years at the University of Rzeszów, he has been conducting research on the use of photodynamic therapy and singlet oxygen dosimetry, as well as the application of magnetic resonance imaging to pharmacokinetics. His achievements have an index H=19 for about 350 IF, he wrote 15 books.
Cheers
Susanna Guatelli
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