26/08/2026
📚 𝗜𝗗𝗬𝗟𝗟𝗔™ 𝗣𝗨𝗕𝗟𝗜𝗖𝗔𝗧𝗜𝗢𝗡 𝗛𝗜𝗚𝗛𝗟𝗜𝗚𝗛𝗧𝗦 𝗛𝟭 𝟮𝟬𝟮𝟲: 𝗥𝗮𝗽𝗶𝗱 𝗡𝗧𝗥𝗞 𝗳𝘂𝘀𝗶𝗼𝗻 𝗱𝗲𝘁𝗲𝗰𝘁𝗶𝗼𝗻 𝗮𝗰𝗿𝗼𝘀𝘀 𝘁𝘂𝗺𝗼𝗿 𝘁𝘆𝗽𝗲𝘀 𝘄𝗶𝘁𝗵 𝘁𝗵𝗲 𝗜𝗱𝘆𝗹𝗹𝗮™ 𝗚𝗲𝗻𝗲𝗙𝘂𝘀𝗶𝗼𝗻 𝗔𝘀𝘀𝗮𝘆*
As part of our H1 2026 Publication Highlight series, we take a closer look at a study by Sura et al. (2026)** that evaluates the Idylla™ GeneFusion Assay for NTRK1/2/3 detection in a pan-cancer, fusion-enriched cohort from two US academic centers.
💡𝗦𝘁𝘂𝗱𝘆 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁𝘀:
- 193 samples evaluated across thyroid cancer, NSCLC, breast cancer, colorectal cancer, pancreatic cancer, and other tumor types
- 95.7% PPA and 100% NPA for unequivocal calls vs. NGS
- NTRK results in only 3 hours with < 3 minutes hands-on time
The study represents one of the largest published NTRK-positive validation cohorts and highlights the potential of 𝗿𝗮𝗽𝗶𝗱, 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 𝘁𝗲𝘀𝘁𝗶𝗻𝗴 𝘁𝗼 𝘀𝘂𝗽𝗽𝗼𝗿𝘁 𝗯𝗿𝗼𝗮𝗱 𝗽𝗮𝗻-𝘁𝘂𝗺𝗼𝗿 𝗡𝗧𝗥𝗞 𝘀𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴 𝗯𝗲𝗳𝗼𝗿𝗲 𝗰𝗼𝗻𝗳𝗶𝗿𝗺𝗮𝘁𝗼𝗿𝘆 𝗡𝗚𝗦.
👉 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗽𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻: https://pubmed.ncbi.nlm.nih.gov/42320753/
👉 𝗗𝗶𝘀𝗰𝗼𝘃𝗲𝗿 𝘁𝗵𝗲 𝗜𝗱𝘆𝗹𝗹𝗮™ 𝗚𝗲𝗻𝗲𝗙𝘂𝘀𝗶𝗼𝗻 𝗔𝘀𝘀𝗮𝘆: https://www.biocartis.com/en/research/research-assays/idylla-genefusion-assay
*For Research Use Only (RUO), not for use in diagnostic procedures.
** Sura, G. H. et al. (2026). Validation of NTRK Fusion Detection Using an Ultrarapid, Fully Automated Cartridge-Based PCR Assay. The Journal of Molecular Diagnostics : JMD, S1525-1578(26)00105-4. https://doi.org/10.1016/j.jmoldx.2026.06.002