08/26/2026
In one of the strangest psychedelic studies ever conducted, researchers recruited 33 professional religious leaders from Christianity, Judaism, Islam and Buddhism and gave them high doses of psilocybin to see what would happen to their spiritual lives.
They included priests, rabbis, ministers, an Islamic leader and a Zen Buddhist roshi — people who had already spent years or decades praying, meditating, studying scripture and contemplating the divine.
Yet after their psilocybin sessions, more than 90% described the experience as among the most spiritually meaningful and sacred of their lives. Around 42% reportedly ranked it as the single most profound experience they had ever had.
Participants received substantial doses of psilocybin while lying down with eyeshades and music, with trained facilitators present. Many reported classic features of mystical experience: unity, sacredness, transcendence of time and space, awe and a powerful sense that what they experienced was profoundly real.
But perhaps the most interesting findings appeared afterward. Sixteen months later, 79% reported lasting positive effects on their religious practices and everyday sense of the sacred, while 71% said they had developed greater appreciation for religious traditions other than their own. Around 78% believed the experience had made them more effective religious leaders.
Rather than simply reinforcing existing beliefs, psilocybin appeared in many cases to loosen attachment to rigid interpretations and increase openness toward other spiritual traditions.
The experiences weren't universally blissful. Nearly half ranked their session among the five most psychologically challenging experiences of their lives. One participant described theirs as “dark, empty, terrifying.” No serious adverse events were reported, but the finding underscores how psychologically intense high-dose psychedelic experiences can be.
The study also has important limitations. It was small, participants were predominantly white and male, several major religious traditions weren't represented, and people willing to volunteer for a psilocybin study are hardly representative of clergy generally.
For thousands of years, religions have developed prayer, meditation, fasting, ritual and contemplation as methods for approaching experiences of transcendence. Here, a single supported psychedelic experience produced something that many lifelong religious practitioners considered comparable to — or more profound than — anything they had previously encountered.
A molecule can reliably produce experiences that even people who have spent their lives studying the sacred recognise as among the most spiritually significant experiences they have ever had.
The study: “Effects of Psilocybin on Religious and Spiritual Attitudes and Behaviors in Clergy from Various Major World Religions” published in Psychedelic Medicine.