06/03/2026
A-Z of Brain Health Supplements: M for Magnesium
Magnesium is an essential mineral involved in over 300 enzymatic reactions in the body, and it's getting a lot of mainstream attention for good reason.
Magnesium has solid research backing for sleep quality, anxiety reduction, mood stabilization, migraine prevention/treatment, and even reducing cortisol.
Like a lot of vitamins and minerals, the benefits are most pronounced in people who are actually deficient, and estimates suggest a significant portion of the population is. So If your levels are already optimal, you might not get as big of a benefit.
There are a ton of different types of magnesium supplements. Each one is bonded to a different compound and might have specific benefits in different contexts. Of those types, magnesium l-threonate has been in focus when it comes to the brain benefits. There's evidence magnesium l-threonate can cross the blood brain barrier more effectively than other magnesium products, but there hasn't been any head-to-head human studies showing that magnesium l-threonate is superior to other magnesium sources for cognitive benefits.
Given that magnesium l-threonate is a lot more expensive, I would argue the most overall beneficial type is magnesium glycinate. It offers the best bang for your buck with the lowest risk of GI distress.
Magnesium can also act as a laxative depending on the type so you don't want to overdo it.
When it comes to dose, you want to try to get around 200-400mg of elemental magnesium per day.
Magnesium is a great overall supplement that goes beyond the brain, so it gets an A+