15/07/2026
Hard-to-heal venous leg ulcers (VLUs) often face a common obstacle: slough⁶ and biofilm.⁸
While debridement is a critical part of wound bed preparation, achieving and maintaining a clean wound bed can be challenging when biofilm persists. ⁶,⁷
That's why the latest RCT findings¹ for Aquacel® Ag+ Extra™ with MORE THAN SILVER™ technology are worth a closer look.
In a 12-week multi-country, multi-centre RCT involving hard-to-heal VLUs:
- 95.7% of wounds were fully debrided by Week 12
- Slough was reduced by an average of 88% over 12 weeks
- Sustained improvement in slough reduction was achieved throughout the study period.²
But these outcomes are about MORE THAN debridement alone.
Aquacel® Ag+ Extra™ combines Hydrofiber™ technology with MORE THAN SILVER™ technology to help manage biofilm alongside antimicrobial activity, supporting continuous wound cleaning and progressive removal of slough.²-⁵
Swipe through to see why it takes MORE THAN SILVER™ to support wound healing outcomes.
References:
1. Beraldo S. et al, Effectiveness of an enhanced silver‑containing dressing in hard‑to‑heal venous leg ulcers: a randomised controlled trial, Journal of Wound Care, 2025.
2. Rodger, R., Ljungqvist, J., Hanson, B. & Mackenzie, J., ‘Enhanced silver dressing improves
slough and debridement in venous leg ulcers: post hoc analysis of a randomized controlled trial’, poster presented at the Symposium on Advanced Wound Care (SAWC) Spring, Charlotte, NC, USA, 8–12 April 2026.
3. Parsons D, et al. Enhanced Performance and Mode of Action of a Novel Antibiofilm Hydrofiber„ Wound Dressing. Biomed Res Int. 2016;7616471.
4. Said J, et al. An In Vitro Test of the Efficacy of an Anti‑Biofilm Wound Dressing. Int J Pharm. 2014;474(1–2):177–181.
5. Bowler PG, Parsons, D. Combatting wound biofilm and recalcitrance with a novel anti‑biofilm Hydrofiber® wound dressing. Wound Medicine 14 (2016) 6–11.
6. Murphy et al. International consensus document. Embedding Wound Hygiene into a proactive wound healing strategy. J Wound Care 2022;31:S1–S24.
7. Schneider, R.E., Hamdan, J.V. and Rumbaugh, K.P. (2025) ‘Biofilm dispersal and wound
infection clearance with preclinical debridement agents’, International Wound Journal, 22, e70145.
8. Gurjala AN et al. Development of a novel, highly quantitative in vivo model for the study of biofilm impaired cutaneous wound healing. Wound Rep Reg (2011) 19 400-410.