20/10/2026
🧠 Meet Dr pierre-damien Denechaud ( & Institut des Maladies Métaboliques et Cardiovasculaires), recipient of the & Boehringer Ingelheim European Research Programme on "Multi-System Challenges in Diabetes".
His project, “ADISLET: Role of ADIpose tissue lipolysis on iSLETs in nutrient regulation and type 2 diabetes,” investigates how communication between adipose tissue and pancreatic islets influences insulin and glucagon secretion.
His team demonstrated that fatty acids released through adipose tissue lipolysis can stimulate insulin secretion by acting on pancreatic fatty acid receptors FFAR1 and FFAR4. The research also combined a specialised mouse model with an innovative two-organ-on-chip platform, providing new insights into the relationship between adipose tissue and pancreatic islets.
🗣️ "This programme has provided crucial support for our research, showing that fatty acids from adipocyte lipolysis stimulate insulin secretion. Furthermore, it has enabled us to initiate a collaboration with Matthieu Raoux (Université de Bordeaux) and obtain preliminary data to strengthen our future research." He reflects.
📖 Read the preprint: https://doi.org/10.64898/2026.05.13.724851