18/05/2026
Excited to share our latest publication in the Journal of Natural Products!
This work reports the discovery of new polyketides belonging to the preussomerin family, isolated from the marine-derived fungus Pyrenochaetopsis indica. These are the first sulfur-containing compounds reported within this family, incorporating rare thioglycolic or 2-hydroxymercaptopropionic acid moieties in their structures. Notably, these moieties have been identified in only 17 natural products derived from fungi, highlighting new aspects of the chemical diversity of marine fungi and providing possible insights into their detoxification mechanisms.
This research was carried out within the framework of the HOTBIO project, in collaboration with University of Galway.
This publication is especially meaningful because it represents the first chapter of Georgia Karyofyllidou’s PhD thesis. 👩🏻🔬✨
🔗 Read the article here: https://pubs.acs.org/doi/10.1021/acs.jnatprod.6c00324
Fundación MEDINA
The organic extract of Pyrenochaetopsis indica CF-301929, a fungal strain collected from the Coral Sea in Australia, showed broad-spectrum activity against the fungal phytopathogens Zymoseptoria tritici, Colletotrichum acutatum, Fusarium proliferatum, and Magnaporthe grisea. After extensive purifica...
