01/05/2026
💪 Temozolomide and CCNU 💪
Yesterday we spoke to Georges lovely Oncologist and specialist cancer nurse from B*H and a plan was formulated for the next battle 👊
George will need a MRI to check what's going down in brain town (and hopefully a blood test at the same time whilst he's under general anaesthetic, because after a few horrible blood tests during our 'mini break' at B*H without numbing cream, he would rather cut off his own head than have a blood test awake 😬)
The next course of chemotherapy will be in the next 3/4 weeks and he will continue to take the Temozolomide and another drug called CCNU (Lomustine)
CCNU works by sticking to one of the cancer cell's DNA strands. This stops the cell from growing and dividing into 2 new cells.
Temozolomide works as a
blood-brain barrier-penetrating alkylating agent, it adds an alkyl group to DNA, damaging it and triggering cell death.
So one will hopefully stop mutation and the other will hopefully kill it dead and then spit in its stupid tumor eye.
Temozolomide Will be a stronger dose than previously but a shorter 5 day course. And the CCNU will be a single dose at the beginning of the 5 day course.
They both obviously come with side effects.
The biggest risk with CCNU and Temozolomide is that it may cause Georges white blood cells to drop, therefore making him more vulnerable to infection. They can also cause nausea, vomiting, diarrhoea, constipation, hair loss, damage to the liver, sore mouth or tongue, bleeding gums and other not very cool things. But we are prepared, we have anti sickness meds, a very impressive calpol stock, super awesome ear thermometer, bonjela, E45 cream, a golden ticket to cut every A&E que in the country if a temperature was to rear its ugly head, a maintenence dose of weekend antibiotics. Ice lollys, cosy blankets, Disney +, amazing people around us, and a brave little kid who is ready to grab life by the balls. Let's go Gorgeous George 💪👊🩷
I asked ChatGPT to make a picture for George to give a little visual interpretation of what the chemo meds role are in his life for the next few months. He loved it. Guess which his favourite medication character is 🤔😂
