European Thyroid Journal

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European Thyroid Journal

The European Thyroid Journal publishes papers reporting original research in basic, translational and clinical thyroidology.

The official journal of the European Thyroid Association, publishing basic, translational and clinical thyroidology. 2025 Journal Impact Factor: 4.9/2025 CiteScore: 7.2 Original contributions cover all aspects of the field, from molecular and cellular biology to immunology and biochemistry, from physiology to pathology, and from pediatric to adult thyroid diseases with a special focus on thyroid c

ancer. Readers also benefit from reviews by noted experts, which highlight especially active areas of current research. The journal will further publish formal guidelines in the field, produced and endorsed by the European Thyroid Association.

03/09/2026

✈️ See you in Porto!

The European Thyroid Journal will be attending the 47th Annual Meeting of the European Thyroid Association on 5-8 September.

If you're thinking about your next publication, stop by for a chat and learn more about publishing with the official journal of the European Thyroid Association.

We look forward to meeting you and hearing about your latest research.

27/08/2026

New Consensus Statement: Management of thyroid storm

This consensus statement provides practical recommendations for the diagnosis and treatment of thyroid storm, a rare but life-threatening endocrine emergency. It aims to standardise care, support clinical decision-making, and improve outcomes in patients presenting with thyroid storm.

Developed by an expert panel nominated by the European Thyroid Association, British Thyroid Association, Society for Endocrinology, and Welsh Endocrine and Diabetes Society, this document brings together current evidence and expert consensus to support the management of this critical condition.

🔗 https://doi.org/10.1530/ETJ-26-0043

25/08/2026

New research by Anke Daser et al. identifies tumor necrosis factor (TNFα) as a central regulator linking inflammation to adipogenic suppression, profibrotic signaling, and extracellular matrix (ECM) remodeling in a thyrotropin receptor (TSHR)-immunized mouse model of thyroid eye disease (TED).

TSHR-immunized mice exhibited marked orbital macrophage infiltration and elevated TNFα levels. TNFα induced a strong pro-inflammatory response in orbital fibroblasts (mOFs) and increased hyaluronic acid (HA) production and hyaluronan synthase 2 (HAS2) expression, particularly in TSHR-derived fibroblasts, demonstrating enhanced ECM synthesis under autoimmune conditions.

Enhanced HA/HAS2 induction underscores a disease-specific sensitivity of mOFs to TNFα. Targeting TNFα or its downstream IL-6/TGFβ-ECM axis may offer a promising therapeutic strategy to limit pathological tissue remodeling in TED.

Read the research: https://doi.org/10.1530/ETJ-25-0407

19/08/2026

August is Thyroid and Pregnancy Awareness Month 💙

As we mark Thyroid and Pregnancy Awareness Month, we recognise the importance of continuing to advance understanding of thyroid hormones and thyroid disease during pregnancy.

Supporting this area is a key aim of the European Thyroid Journal Special Collection: Thyroid Disease and Pregnancy, which is currently open for submissions.

The collection will explore the current state of the art in the management of maternal hypothyroidism and hyperthyroidism in pregnancy, with a clinical focus on diagnosis, treatment, and outcomes.

🔗 journals.bioscientifica.com/etj/pages/pregnancy/

18/08/2026

What role does MCT8 play in maternal-to-fetal T4 transport? And could this contribute to the neurodevelopmental features of MCT8 deficiency?

A recent study by Zhongli Chen et al. used an ex vivo human placental perfusion model to investigate whether MCT8 contributes to the transfer of thyroxine (T4) across the placenta. The study explores the possibility that impaired placental transport of maternal thyroid hormone may be an under-recognised mechanism in MCT8 deficiency, potentially affecting neurodevelopment before birth. The authors also examined the transplacental transport of TRIAC, providing further insight into its potential as a prenatal therapeutic approach for MCT8 deficiency.

Read the study: https://doi.org/10.1530/ETJ-26-0003

11/08/2026

Expert Consensus on the Management of Myxoedema Coma

This document provides recommendations for the diagnosis, initial resuscitation, and definitive management of myxoedema coma based on clinician expertise and experience, emphasising a structured approach to diagnosis and management to improve outcomes.

Key elements include:
- early recognition of precipitating factors
- the use of early empiric stress dose glucocorticoids
- supportive care in a high-dependency or intensive care setting
- cautious thyroid hormone replacement
- guidance on ventilatory and circulatory support, correction of electrolyte and metabolic disturbances, and monitoring of therapy

Read the consensus statement: https://lnkd.in/eFZzBUBw

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Developed following nomination of panel members by the European Thyroid Association, British Thyroid Association, Society for Endocrinology, and Welsh Endocrine and Diabetes Society (WEDS).

06/08/2026

📢 Call for Papers: Autoimmune Thyroid Diseases (AITDs)

As advances in immunology, genomics, and precision medicine accelerate, new insights are reshaping how we understand, diagnose, and manage AITDs—this collection provides a timely platform for deeper scientific exploration.

The Collection Editors invite high-quality manuscripts that help define the next era of innovation in AITDS, addressing emerging topics such as:
🔹 Novel immunopathogenic pathways
🔹 Environmental and genetic risk interactions
🔹 Biomarker discovery
🔹 Evolving therapeutic strategies
🔹 Thyroid autoimmunity across the lifespan
🔹 Impact of AITDs on metabolic, cognitive, and cardiovascular health.

They also welcome cutting‑edge studies that deepen understanding of thyroid eye disease—its pathogenesis, diagnostics, clinical stratification, and treatment.

View the collection: https://journals.bioscientifica.com/etj/pages/autoimmunity-and-thyroid

05/08/2026

NEW GUIDELINES
2026 ETA guideline on interference in immunoassay measurements used in assessment of thyroid function (https://lnkd.in/eNdUG9ST)

"Here, we summarise current understanding of immunoassay interference, outline approaches for detection and resolution, and offer guidance for clinicians and clinical laboratory professionals managing patients with confirmed or suspected assay interference in tests used to measure TH or related substances." — Irene Campi et al. (Authors of 2026 ETA guideline on interference in immunoassay measurements used in assessment of thyroid function)

28/07/2026

A new review by Laura Croce (Maugeri) et al. critically reviews current evidence and highlights emerging topics in the interaction between obesity and the thyroid axis.

The review draws attention to the complexity of thyroid responses across different degrees of obesity and during weight loss, as well as changes in thyroid-stimulating hormone (TSH) and thyroid hormone levels.

Read the review: https://doi.org/10.1530/ETJ-26-0082

21/07/2026

New review by Vicente Rodrigues Marczyk and Jennifer Rui Wang explores how single-cell RNA sequencing (scRNA-seq) has advanced understanding of tumour heterogeneity in papillary and anaplastic thyroid carcinomas.

The authors comprehensively review the application of scRNA-seq to characterising tumour heterogeneity, dissecting the tumour microenvironment, and uncovering intratumor heterogeneity with potential therapeutic implications in PTC and ATC.

Read the review: https://doi.org/10.1530/ETJ-25-0141

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