01/09/2026
REDEFINING ACNE as a systemic inflammatory disease
Inflammation is a hallmark of acne, with the characteristic red lesions being the physical manifestation. However, the inflammatory process begins long before these appear, and managing this is key to long-term resolution.
Acne vulgaris (AV) is not a self-limiting adolescent rite of passage or a superficial cosmetic complaint; it is a chronic, systemic inflammatory dermatosis affecting approximately 80% of adolescents and young adults globally. Because AV lesions preferentially manifest on highly visible, sebaceous-gland-dense regions—specifically the face, upper chest and back—the disease imposes a profound psychological burden, significantly impairing patient quality of life.
The gut-skin axis is a powerful pathway that regulates the immune system. Diets high in refined carbohydrates and low in dietary fibre alter the balance of gut bacteria, causing dysbiosis, a state marked by a drop in beneficial microbes and an
overgrowth of pro-inflammatory bacteria.
Improving acne requires systemic metabolic changes designed to lower overall body inflammation and restore a healthy bacterial balance.
Dietary and supplemental protocols are available.