27/05/2026
If you are affected by RSD (Rejection Sensitive Dysphoria) then what are your treatment options when it comes to medication? I’m afraid I am at great odds here with Dr William Dodson, the man who coined the term RSD, since he recommends alpha-2-agonists like clonidine or guanfacine - BUT there is no published trial data at all to back this up.
It’s important to note that these are unusual drugs. They are a treatment for ADHD in children (although I have never known a child be prescribed them) but they are not licenced in the UK or USA for ADHD in adults. So this is not like optimising ADHD treatment, it is trialling something new - and when you do that you need evidence that the benefits outweigh the harms.
Dr Dodson quotes success rates of around 30% in his clinical practice, but this is not from a trial, it is just his clinical experience. This could be placebo, it could be 3 patients out of 10 or 300 out of 1000 - we don’t know as he hasn’t shown anyone the data. And yet, because he has written about it online, if you Google it you will be quoted this figure as if it is established proof!
Dr Dodson justifies his recommendation to treat without trial evidence on the grounds that people need treatment now and so it would be unethical to wait for the evidence. That is a very dangerous path in medicine and medical history is littered with treatments that were thought to be beneficial but did more harm than good. And what if he’s right and they are good treatments? Well without good trial evidence they will never become established as a mainstream treatment and people will miss out!
These drugs are also not without their issues - stopping them suddenly can cause a huge spike in blood pressure for instance - but then that’s ok because when did anyone with ADHD ever forget to take their medication??! He also recommends drugs called monoamine oxidase inhibitors (MAOIs) - really? These are old fashioned antidepressants that may have helped some people but caused a lot of problems, especially in their interactions with other medicines (including ADHD meds) and a wide range of foods. No thanks!