05/07/2026
There’s only one way to really learn if a medication works, and that is through clinical trials. Understanding the mechanism of how a medication might work is important in developing new treatments, but it does not tell us if a drug works or not. Which is why the doubts about the serotonin theory for depression are interesting, and important for research, but should have very little bearing on anyone who takes them, or on me as a GP who might prescribe them.
The placebo effect is powerful, and so we need placebo-controlled trials to be able to work out if a medication is better than placebo, and the evidence is consistently that SSRIs are more effective than placebo. Does that mean I always prescribe them when someone has anxiety or depression? Absolutely not, because most people get better without them and all the other aspects of recovery - lifestyle changes, removing stressors, therapy and so on - are so much more important. But sometimes it is hard to do that, and these medications can really help.
Are there any downsides? Yes, and I have talked about these in previous posts and in my book Your Worry Makes Sense. I won’t cover that area in this post, as this post is trying to answer one question - do they work?
And anyone eagle-eyed may have noticed that the pill packet on the video isn’t for an SSRI at all! But you have to use what is at hand, don’t you! 😊😂