03/06/2026
We all know the HPA axis story. A stressor - neurological, physical, inflammatory, metabolic, circadian stimulates cortisol and a cascade of responses ripples through tissues, organs, and entire systems.
But the body is far more than an HPA axis, even, than the HPA-Ovarian-Thyroid axis think- bigger….
Think HPAOTGBBKLAVUIM (Deanna Minich beautifully articulated this concept at IPM last week ❤️)
HPA. Ovarian. Thyroid. Gut. Bone. Biliary. Kidney. Lung. Adipose. Vasculature. Urogenital.Immune.Muscle.
Because that's what the biology is - a single, exquisitely dynamic web. And the signals moving across it? Hormones, cytokines, myokines, adipokines, osteokines. Not one-way broadcasts. Constant, bidirectional conversation.
Think of it like a spider's web stretched across the body. Stressors “land”, the web absorbs them — beautifully, intelligently — until the cumulative load becomes too much. The threads begin to buckle. And that's when symptoms emerge.
The web-system is a symphonic circuit, not a series of solo performances.
Messengers act within interconnected feedback loops: each signal both shaped by and shaping the environment around it. So when fatigue, low mood, weight changes, or cycle disruption appear, the instinct to reach for a single explanation (menopause, sub-optimal thyroid just because of a low T3 or out “functional range” TSH) misses the point. These symptoms more often reflect signalling disruption, not an absolute deficiency.
Applying a isolated replacement model, whether MHT or supplements for thyroid “support”, without identifying the upstream drivers of that disruption, is patching individual threads while the tension across the whole web remains.
The web doesn't work in isolation. Neither should our thinking.