25/08/2025
In this "series" of two new articles, a group at the The Royal Veterinary College (RVC) has shown that veterinary medicine can actually be a "trail blazer”. by emploing 3D organ explants. Here, VetMed can be a “trail-blazer” as VetMed can do a lot more than what can be done in human medicine. This will not only impact on our understanding of processes that are yet a "black box", but will change these into5 0 shades of grey, it will also aid the reduction of animals used for in-vivo studies as well as potentially reducing the use of fetal calf serum. And it will become even more meaningful when we start combining different approaches, incl organ-on-a-chip technologies
In the first publication, the group shows the development of precision cut gut slices in chicken.
José M. Jaramillo-Ortiz, Samruddhi A. Deosthali, Damer P. Blake, Dirk Werling,
Short communication: Recombinant yeast as an oral vaccine carrier - direct in vivo interaction with chicken gut epithelium, Research in Veterinary Science,
Volume 195, 2025, 105845,
https://www.sciencedirect.com/science/article/pii/S0034528825003194
In the second publication, they demonstrated the establishment of bovine precision cut udder slices and the impact fetal calf serum has on the immune response:
Filor V, Myslinska J, Saliani A, et al. Pre-stimulation of precision-cut bovine udder slices with zymosan before LPS exposure indicates aspects of trained immunity especially in the absence of FCS. Innate Immunity. 2025;31. doi:10.1177/17534259251360484
https://journals.sagepub.com/doi/10.1177/17534259251360484