30/03/2026
Omega-3
For some time now, pharmacy journals and physicians have been warning about higher doses of Omega-3.
However, in the underlying relevant studies that link increased intake of Omega-3 fatty acids (usually >1 g/day EPA/DHA) with a higher risk of cardiac arrhythmias (especially atrial fibrillation), NO natural wild fish oils in their natural triglyceride form (TG), in liquid form with adequate oxidation protection and a TOTOX value below 10 (!) were tested.
Instead, these studies exclusively used pharmaceutical, artificially/synthetically produced or chemically modified preparations in capsule form. Although these products are often derived from fish oil, they have been highly purified, concentrated, and chemically altered (e.g., into ethyl ester or free fatty acid forms). They are not ānaturalā wild fish oils as found in unprocessed liquid triglyceride form.
These products are not natural triglycerides (as found in unprocessed wild fish oil or some OTC ārTGā products). Ethyl esters are chemically modified (esterified with ethanol), and free fatty acids (carboxylic acids) are also modified to improve bioavailability. All were administered in capsule formāno liquid natural oils were used.
There is not a single study that has directly tested natural wild fish oilāi.e., pure, stabilized rTG oil in liquid formāat doses of 4 to 7 grams per day with respect to atrial fibrillation risk. The warnings about higher-dose Omega-3 from the medical community come exclusively from RCTs using pharmaceutical ethyl esters (such as Vascepa, Omacor) or free fatty acidsāand these were conducted at high doses (typically 4 grams or more).
More recent data, for example from the UK Biobank analysis (2025/26, OmegaQuant study), even suggest that higher Omega-3 blood levels (regardless of whether from fish or supplements) are associated with a lower AF risk, and that supplement use itself is no longer associated with increased risk after proper adjustment. This argues against excessive alarm.
The difference? Natural rTG forms (such as high-quality liquid wild fish oil) are absorbed more slowly and steadily than ethyl esters. This may help avoid the rapid fluctuations seen with pharmaceutical products, which could potentially trigger arrhythmias.
