24/03/2024
Treatment-induced secretion of WNT16B promotes tumor growth and acquired resistance to chemotherapy
Implications for potential use of inhibitors in cancer treatment
Linda M. Johnson, Douglas K. Price & William D Figg
Pages 90-91 | Received 18 Sep 2012, Accepted 22 Oct 2012, Published online: 31 Oct 2012
Cite this article
https://doi.org/10.4161/cbt.22636
Abstract
Innate or acquired resistance to chemotherapy presents an important and predictable challenge in cancer therapy. Malignant tumors consist of both neoplastic and benign cells such as stromal fibroblasts, which can influence the tumor’s response to cytotoxic therapy. In a recent article in Nature Medicine, Sun et al. show that increased expression of Wnt family member wingless-type MMTV integration site family member 16B (WNT16B) by the tumor microenvironment in response to cytotoxic damage and signals through the canonical Wnt pathway to promote tumor growth and chemotherapy resistance. Such findings outline a mechanism by which cytotoxic therapies given in cyclical doses can actually augment later treatment resistance and may open the door to new areas of research and to the development of new therapeutic targets that block the DNA damage response program.
This means that chemotherapy induces tumours to be more aggressive and resistant to treatments by initiating the WNT16B protein mechanism. The medical pharmaceutical system see this as an opportunity to develop further drugs to combat WNT16 B which their treatments initiate.
I would ask, what about the millions of people that have been treated with chemo and radiotherapy since there introduction in the 1930s and the initiation of cancer progression
Innate or acquired resistance to chemotherapy presents an important and predictable challenge in cancer therapy. Malignant tumors consist of both neoplastic and benign cells such as stromal fibrobl...