06/04/2020
TAHITIAN NONI
List of Human Studies of Morinda, Inc. Product & Ingredients
=====================================
TNJ, Extra and Max
Safety clinical trial
− Conducted by the British Industrial Biological Research Association (BIBRA).
− Published in Pacific Health Dialog and the Journal of Food Science
− 96 people, double-blind, placebo-controlled, one-month trial, high dose of 750 ml/day (¾ bottle)
− TNJ was found to be absolutely safe & reduced number of illness related events
− Summary Report URL: http://www.ncbi.nlm.nih.gov/pubmed/20443518
Health Benefits in heavy smokers
− Antioxidant
1. Conducted by the University of Illinois College of Medicine and TNI R&D
2. Published in Chemistry Central Journal
3. 285 people, double-blind, placebo-controlled, one-month trial
4. As little as 1 serving TNJ per day (30 mL or 1 oz) lowered free radicals significantly (fruit juice placebo had no significant effect)
5. Report URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765950/?tool=pubmed
− DNA protection- aromatic DNA adducts in heavy smokers
1. Conducted by the University of Illinois College of Medicine
2. Published in the journal, Nutrition and Cancer
3. 203 people, double-blind, placebo-controlled, one-month trial
4. As little as 1 serving TNJ per day (30 mL or 1 oz) lowered amount of DNA damage by approximately half
5. Report URL: http://www.ncbi.nlm.nih.gov/pubmed/19838937?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2
− Cholesterol & triglyceride lowering- in heavy smokers
1. Conducted by the University of Illinois College of Medicine
2. 132 people, double-blind, placebo-controlled, one-month trial
3. Drinking TNJ significantly reduced cholesterol levels, triglycerides, and hs-CRP. TNJ also decreased LDL and homocysteine, but increased HDL. Placebo had no effect
4. Report URL: http://www.hindawi.com/journals/tswj/2012/594657/
− DNA protection- lipid peroxide derived DNA adducts in heavy smokers
1. Conducted by University of Illinois College of Medicine
2. 245 people, double-blind, placebo-controlled, one-month trial
3. TNJ reduced the amount of lipid peroxide caused DNA damage 44.6–57.4%.
4. −Report URL: http://onlinelibrary.wiley.com/doi/10.1002/fsn3.21/pdf
5. Joint health of the neck (cervical spondylosis)
− Conducted by the University of Lagos College of Medicine
− Published in Nigerian Journal of Health and Biomedical Sciences
− 90 people, therapeutic control groups, one-month trial
− 1 serving of TNJ alone improved range of movement & pain; combination of TNJ & standard therapy had further increased benefits
− Report URL: http://www.ajol.info/viewarticle.php?id=29710
6. Energy/Endurance
− Conducted by the Moscow Scientific and Practical Center of Sports Medicine
− Published in Journal of Medicinal Plants Research
− 40 people, placebo-controlled, three-week trial
− TNJ increased endurance by 21% and increased antioxidant activity by 25%. Placebo (blackberry juice) had no effect
− Report URL:http://www.academicjournals.org/jmpr/PDF/pdf2008/July/Palu%20et%20al.pdf
7. Immune boosting & antioxidant
− Conducted by Tianjin Medical University
− Published in the journal, Chinese Medical Research & Clinical
− 12 people, two-month pilot study
− TNJ increased adaptive immune system activity by 32% and innate immune system activity by 30%. TNJ decreased oxidative stress in the body by 19%.
− Results discussed in Section 7 and Table 1 of English language review paper available online at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920423/.
8. Drug screen test
− Conducted by TNI R&D
− Published in Journal of Medicinal Plants Research, in same paper as endurance trial
− 6 people, pilot study with urine drug screening tests
− TNJ does not contain illegal drugs or cause false positive results
− Report URL:http://www.academicjournals.org/jmpr/PDF/pdf2008/July/Palu%20et%20al.pdf
9. Hypertension trial
− Conducted by Brigham Young University Hawaii
− Published in American Chemical Society Symposia Series No. 993, Functional Food and Health
− 10 people, one-month open label trial
− 4 oz. TNJ per day significantly decreased blood pressure, especially systolic blood pressure
− Report URL: http://pubs.acs.org/doi/abs/10.1021/bk-2008-0993.ch039
10. Menopause
− Conducted by the University of Illinois College of Medicine
− Published in The Journal of Alternative & Complimentary Medicine
− 8 post-menopausal women, placebo-controlled, three-month pilot study
− TNJ increased improved mood and energy, attenuated hearing loss, and showed evidence of potential anti-osteoporosis effect
− Report URL: http://www.liebertonline.com/doi/abs/10.1089%2Facm.2004.10.737
11. Cholesterol—non-smoker
− Conducted by Brigham Young University Hawaii
− 10 people, one-month pilot study
− Already healthy cholesterol values remained within healthy normal range
− TNJ has mild cholesterol lowering & HDL raising potential in non-smokers within the high-end range of normal. This displays adaptogenic activity.
− Available online athttp://www.japsonline.com/admin/php/uploads/626_pdf.pdf
12. Osteoarthritis.
− Conducted by University of Illinois at Chicago, College of Medicine at Rockford
− Open label three-month intervention trial with 82 osteoarthritis patients.
− Dose was 3 oz. of TNJ per day
− Significant improvements in symptoms, such as pain and mobility, were observed, as well as improvements in quality of life factors. Clinical laboratory tests revealed a large margin of safety.
− Publication of the full paper is in process
− The registration for this clinical trial is found online at http://www.clinicaltrials.gov/ct2/show/NCT01070264?term=noni&rank=2
− Publication citation—Wang MY, et al. Morinda citrifolia L. (noni) improves the Quality of Life (QoL) in adults with Osteoarthritis. Functional Foods in Health and Disease 2011, Volume 2 (February 20, 2011).
− Available online at http://www.functionalfoodscenter.net/files/43301924.pdf.
13. Effect of TNJ on maximal oxygen uptake (VO2) max in cyclists
− Conducted at the University of Chile
− 30 volunteers, three groups (TNJ, placebo, & reference groups)
− Two weeks TNJ or placebo supplementation for two weeks
− TNJ group had increased VO2max and 50 Watt VO
− Available online athttp://www.maxwellsci.com/print/crjbs/v5-177-181.pdf
14. Effect of TNJ on energy levles and serum cortisol
− Conducted at the University of Hamburg
− Human pilot study demonstrating that consuming TNJ helps to increase cortisol levels temporarily, which may increase resistance to stress and increase physical energy/power.
− The data is currently published in a University of Hamburg PhD dissertation
− The dissertation is available online athttp://www.sub.uni-hamburg.de/opus/volltexte/2009/4090/pdf/NoniPDF.pdf
15. Protective effect of TNJ on exercise induced muscle damage and endurance
− Conducted at the University of Port Harcourt.
− 60 participants, placebo controlled, 30-day trial
− TNJ improved endurance in university athletes.
− TNJ lowered serum creatine kinase levels, indicating protection against exercise induced muscle damage.
− Available online athttp://www.idosi.org/wjss/7(1)12/8.pdf
16. Effect of TNJ on HbA1c of type 2 diabetic
− Conducted at the University of Hamburg
− Human pilot study demonstrating that consuming TNJ decreases HbA1c in type 2 diabetes patients.
− Report URL (German abstract): https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0033-1341781
17. Effect of TNJ on gingivitis
− Conducted at the University of Hamburg
− Human pilot study demonstrated that consuming TNJ decreased gingivitis symptoms of bleeding and inflammation.
− The data is currently published in a University of Hamburg PhD dissertation
− The dissertation is available online athttp://www.sub.uni-hamburg.de/opus/volltexte/2009/4377/pdf/DissMorindacitrifolia.pdf
18. Anti-AGE trial in overweight adults
− Conducted at the University of Jakarta
− 34 people, eight week open-label trial
− Daily ingestion of Max reduced AGE levels, as measured by the AGE Reader.
− Published in the International Journal of Food Science (http://www.hindawi.com/journals/ijfs/2014/276950/).
19. TNJ Antioxidant—non-smoker
− Conducted at University Medical School, Hamburg and IVA ltd./Ural State University of Economics Dept. of Chemistry
− 30 people, one-hour absorption study, open label trial
− TNJ caused a 2-fold and 4.6-fold increase in antioxidant activities of blood plasma and blood cell mass, respectively, when compared to orange juice
− This study has not yet been published.
20. Antioxidant trial of Extra & Max
− Conducted at IVA ltd./Ural State University of Economics Dept. of Chemistry
− 40 people, 40-50 min absorption study, open label trial
− Extra and Max caused a 5.1 and 25-fold increase, respectively in antioxidant activities of red blood cell mass when compared to blood orange juice
− This study has not yet been published
21. Max cognitive performance trial
− Effect of TNJ on serum lactate—Austrian soccer and handball athletes
− Human pilot study demonstrating that consuming TNJ decreases serum lactate levels during exercise.
− Not yet published
22. Max cognitive performance trial
− Conducted at Brigham Young University- Hawaii
− 11 university students
− 3 week open-label pilot study
− Daily ingestion of Max improved performance on cognitive function test.
− This study has not yet been published as full paper.
23. Cross-sectional population study with 3,913 Japanese
− 3,913 Japanese participants
− AGE levels measured with AGE reader and daily iridoid intake determined from daily TNJ, Extra, or Max ingestion rates.
− Data analysis revealed that iridoid intake has a dose-dependent effect on lower AGE scores.
− Published in the International Journal of Food Science (http://www.hindawi.com/journals/ijfs/2014/276950/).
24. Max and TNJ anti-AGE and weight loss trial in obese adults
− Conducted by the Institute of Nutrition of the Russian Federation
− 90 people, six-week trial
− Daily ingestion of Max reduced AGE levels, improved atherogenic index, improved weight loss, increase energy metabolism, conserved muscle mass.
− Study results were presented at the 249th American Chemical Society National Meeting and Exposition (https://ep70.eventpilot.us/web/page.php?page=IntHtml&project=ACS15spring&id=2143008).
− TNJ and Max results also published in Russian language scientific journal; available online at http://vp.geotar.ru/en/jarticles_diet/371.html?SSr=1501339ed300ffffffff27c__07e0020b000f2b-3ce6
25. Epidemiological survey of the benefits of noni juice among Europeans.
− Two surveys were conducted to qualitatively and quantitatively analyze the beneficial effects of noni juice as reported by European consumers.
− About 30 different benefits were reported, with the most frequent being more energy (39.3%), better overall feeling (20.8%), reduction of peripheral pain (17.1%), fewer infections (10.3%), improved sleep (8.4%), fewer problems with digestion and stomach (8.9%), and fewer allergies and asthma (7.1%).
− Report available online at https://web.a.ebscohost.com/ehost/pdfviewer/pdfviewer?vid=2&sid=5935309a-dbd8-4006-a3f1-96e5dfd0fec0%40sessionmgr4008
26. Effect of TNJ on type-2 diabetes
− Twenty type-2 diabetes patients drank TNJ (2mL/kg body weight) daily for 8 weeks after they underwent a standard treatment regimen including carbohydrate reduced diet and treatment with an antidiabetic drug and/or insulin.
− TNJ ingestion resulted in a significant decrease in average morning blood sugar levels in hyperglycemia patients but did not in those with normal blood sugar levels.
− TNJ also reduced the average HbA1c value and CRP levels significantly.
− Study published in Evidence-Based Complementary and Alternative Medicine, Volume 2018, Article ID 3565427. https://doi.org/10.1155/2018/3565427.
Noni leaves
27. Noni leaf serum protection of skin
− Clinical trial involving 25 people
− Noni leaf serum, composed of leaf extracts, protected the skin against ultraviolet (UV) light exposure and reduced erythema (redness & swelling)
− Published in Journal of Natural Medicines
− The report URL, as an abstract, is http://www.springerlink.com/content/44122428mlt17404/
FIT clinical trial
28. Open label clinical trial of efficacy of Morinda Bioactives FIT body
− 22 people, conducted in-house.
− Published in North American Journal of Medical Sciences
− Paper available online at http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271418/
DEFY clinical trial
29. Open label clinical trial of efficacy of DEFY skin care regimen
− Six-week clinical trial conducted with 49 women
− Published in Current Research Journal of Biological Sciences
− Paper available online athttp://www.maxwellsci.com/print/crjbs/v4-310-314.pdf
Noni Seed oil
30. Open label clinical trial of the topical safety of noni seed oil
− Repeat insult patch test with 49 volunteers to assess the non-allergenic nature of noni seed oil
− Paper reporting trial results is available online at http://www.scirp.org/journal/PaperInformation.aspx?paperID=20117
31. Open label clinical trial of the anti-acne activity of noni seed oil
− Four-week trial with 23 adolescent volunteers demonstrating noni seed oil has potential anti-acne activity
− Paper reporting trial results is available online at http://www.scirp.org/journal/PaperInformation.aspx?paperID=20117
TruAGE Therapy
32. A.G.E. Therapy Gel
− A 12-week open-label clinical trial was conducted with 39 women, ages 49-59 years.
− Adjusted average 12-week AGE score was significantly less than the baseline score, equating to an approximate decline of nine AGE-associated years. Significant improvements in facial skin firmness and skin elasticity were also evident.
− Study presented at the 12th International Symposium on the Maillard Reaction, 2015, in Tokyo Japan (see P31, on page 136 of the meeting Program & Abstract available at http://www.imars.org/online/wp-content/uploads/2015/09/Program-Abstract-low-reso.pdf).
TruAge Sugar Stop
33. Open label clinical trial of the anti-AGE and weight loss activity of Sugar Stop
− Eleven week open-label trial with 30 adults, where AGE scores declined significantly
− The change in AGE scores corresponded to an average decrease of 8.83 AGE-associated years
− Participants also experienced significant declines in weight and fat mass
− Paper reporting trial results is available online athttp://maxwellsci.com/print/ajfst/v8-725-729.pdf
TeMana
34. Open label clinical trial of TeMana Noni Brightening Serum and Facial Shield
− A 4-week, open-label clinical trial with 10 healthy, adult, volunteers
− There were improvements in skin texture and brightness, less pigmentation, and reduction in red skin tone.
− Significant improvements also occurred in fine wrinkle, skin texture, skin clearness, skin spots, skin brightness and pore scores.
− Published paper available online athttp://www.pharmasm.com/download1.php?articleid=1008&download_file=20170128012125_02_brett.pdf
35. TeMana Noni Brightening Serum anti-wrinkle efficacy test
− A 5-week, open-label clinical trial with 15 adult women
− Use of the product decreased appearance of wrinkles near the eye.
− Study not published, internal document.
36. TeMana Noni + Collagen
− A 21-day open-label trial with a combination of noni fruit juice, hydrolyzed marine collagen, and other ingredients (TeMana Noni + Collagen) on skin viscoelastic properties in healthy Japanese adults.
− During the trial, skin biomechanical properties improved through enhanced collagen and elastin deposition in the skin, reduced skin glycation and improved skin hydration.
− Published in the International Journal of Clinical Dermatology 2018; 1(1): 22-27. http://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20180101.15.pdf.
37. TeMana Noni + Collagen hair study
− An 8-week open-label trial, with a 4-week follow up, of the effect of TeMana Noni + Collagen on hair strand thickness and other hair quality measurements (smoothness, graying, split ends, etc.).
− Use of TeMana Noni + Collagen significantly increased hair strand thickness and other quality measurements.
− Published in Medical Science Digest 2019; 45 (13): 798-801, a Japanese medical journal.
Pac Health Dialog. 2009 Nov;15(2):21-32. Research Support, Non-U.S. Gov't