10/12/2017
Antiglycative activity of our novel bioactive may have the potential opportunity in preventing or delaying neuron degenerative diseases.
Further research in clinical trial in human volunteers will address the potential therapeutic strategy to prevent the diseases.
Supporting research data elucidate many more new avenue to substantiate our research on functional food bioactive.
The researchers found that a neuron “starts with around 600 mutations” in an infant, “and the mutations accumulate about one every two weeks, so that by the time a neuron is 80 years old it has about 2,400 or so,” says Christopher Walsh of Harvard Medical School and Boston Children’s Hospital who authored the study. “In general, our numbers pick up right where [Vaccarino’s] leave off,” he says.
“It’s nice to see the two approaches getting similar answers,” says McConnell. “It’s very good news for folks like me that do single-cell sequencing.”
The second study also looked at brain cells from two individuals with neurodegeneration caused by defects in DNA repair enzymes, finding them to have roughly 2.5 times more SNVs than age-matched controls.
“About one percent of the mutations are likely to be functional in the sense that they disrupt a protein,” says Walsh, “so by the time you’re 80 years old there’s about one in a thousand neurons that has had a gene essentially knocked out.” Mutation accumulation could therefore be “a reasonable model for how age-related cognitive decline might come about,” he says.
Walsh’s team also noted that the types of SNVs varied with age, with those apparently caused by oxidative damage being more prevalent in the elderly. That fits “with previous literature that suggests that one cause of aging in the brain might have to do with oxidative damage,” he says. “So that has me eating a lot of blueberries and drinking a lot of red wine.”
