https://www.facebook.com/102423788483883/

CamH&N, Phnom Penh (2026)

12/05/2026

ថ្នាំចាក់ (Semaglutide) មួយសប្តាហ៍ម្តង ជួយកាត់បន្ថយការទទួលទានគ្រឿងស្រវឹង ចំពោះអ្នកជំងឺដែលមានបញ្ហាប្រើប្រាស់គ្រឿងស្រវឹង (AUD) និងមានជំងឺលើសទម្ងន់ (Obesity)។
១. ការរកឃើញសំខាន់ៗនៃការព្យាបាល៖
តាមរយៈលទ្ធផលនៃ "ការសាកល្បងដោយចៃដន្យដែលមានការគ្រប់គ្រង" (Randomized Controlled Trial) ដែលជាការសិក្សាដំបូងបង្អស់ បានបង្ហាញថា ថ្នាំប្រភេទ GLP-1 receptor agonist (ឈ្មោះពាណិជ្ជកម្មគឺ Semaglutide) មានប្រសិទ្ធភាពខ្ពស់ចំពោះអ្នកជំងឺដែលស្វែងរកការព្យាបាលបញ្ហាគ្រឿងស្រវឹង (AUD) ហើយមានជំងឺលើសទម្ងន់រួមជាមួយគ្នា។ ក្រៅពីកាត់បន្ថយការផឹក វាក៏ផ្ដល់លទ្ធផលវិជ្ជមានទៅលើបញ្ហាផ្សេងៗទៀតដែលពាក់ព័ន្ធនឹងគ្រឿងស្រវឹងផងដែរ។
២. តើអ្វីទៅជា AUD?
AUD (Alcohol Use Disorder) គឺជាជំងឺខួរក្បាលរ៉ាំរ៉ៃ ដែលមានលក្ខណៈសម្គាល់ដូចជា៖
• ការបាត់បង់ម្ចាស់ការលើការផឹក (មិនអាចបញ្ឈប់ការផឹកបាន)។
• ការប្រើប្រាស់គ្រឿងស្រវឹងតាមបែបបង្ខំ (មានអារម្មណ៍ថាត្រូវតែផឹក ទោះដឹងថាវាប៉ះពាល់ដល់សុខភាពក៏ដោយ)។
៣. ស្ថានភាពបច្ចុប្បន្ននៃការព្យាបាល៖
ទោះបីជាមានការសិក្សាស្រាវជ្រាវជាច្រើនទសវត្សរ៍ក៏ដោយ រហូតមកដល់ពេលនេះ មានថ្នាំតែ ៣ ប្រភេទ ប៉ុណ្ណោះដែលត្រូវបានអនុម័តដោយរដ្ឋបាលចំណីអាហារ និងឱសថអាមេរិក (FDA) សម្រាប់ព្យាបាលជំងឺ AUD គឺ៖
1. Disulfiram
2. Acamprosate
3. Naltrexone
៤. សារៈសំខាន់នៃការសិក្សានេះ៖
ដោយសារតែបច្ចុប្បន្នមានថ្នាំតិចតួចពេកសម្រាប់ព្យាបាលជំងឺញៀនស្រា ការរកឃើញថាថ្នាំ Semaglutide (ដែលគេស្គាល់ជាទូទៅសម្រាប់ព្យាបាលជំងឺទឹកនោមផ្អែម និងសម្រកទម្ងន់) អាចជួយព្យាបាល AUD បាននោះ គឺជាក្តីសង្ឃឹមថ្មីមួយ។ វាបង្ហាញពីតម្រូវការបន្ទាន់ក្នុងការស្វែងរកវិធីសាស្ត្រព្យាបាលដែលមានប្រសិទ្ធភាពជាងមុន សម្រាប់អ្នកជំងឺដែលប្រឈមមុខនឹងបញ្ហាទាំងពីរនេះ (ញៀនស្រា និងលើសទម្ងន់)។
សេចក្តីសន្និដ្ឋាន៖
ការសិក្សានេះផ្ដល់ជាភស្តុតាងថា ថ្នាំសម្រកទម្ងន់ និងទឹកនោមផ្អែមប្រភេទ Semaglutide អាចនឹងក្លាយជាឱសថដ៏មានសក្តានុពលនាពេលអនាគត ក្នុងការជួយមនុស្សឱ្យផ្ដាច់ស្រា ឬកាត់បន្ថយការផឹកស្រាបានយ៉ាងមានប្រសិទ្ធភាព។
ប្រសិនបើអ្នកចង់អានព័ត៌មានលម្អិតបន្ថែមពីប្រភពដើម អ្នកអាចចូលទៅកាន់តំណភ្ជាប់ដែលបានផ្ដល់ជូន៖ https://mdsc.pe/3RbZiD0

23/03/2026

Novel GLP-1-based Medications for Type 2 Diabetes and Obesity

Next-gen multi-receptor incretin agonists (GLP-1/GIP, GLP-1/glucagon, GLP-1/amylin, triple agonists) and oral small‑molecule GLP-1 RAs like orforglipron can produce >20% weight loss, better glycemic control, and kidney/liver benefits but we’re still figuring out how to manage tolerability, sarcopenia risk, and long-term use in a chronic disease.

https://academic.oup.com/edrv/article-abstract/47/2/159/8276515?login=false

18/02/2026

New obesity guideline release 💯

American Diabetes Association Pharmacologic Treatment of Obesity in Adults: Standards of Care in Overweight and Obesity

ADA adds to the list of guidelines published this past year summarizing the evidence of obesity medications.

A particular emphasis on selecting a treatment based on the particular concurrent obesity comorbidities present.

https://diabetesjournals.org/docm-care/article/doi/10.2337/doci25-0008/164233/Pharmacologic-Treatment-of-Obesity-in-Adults

05/02/2026

Common Liver Diseases :

🟣 Fatty Liver (Hepatic Steatosis)

→ Excess triglyceride accumulation in hepatocytes
→ Common causes: obesity, type 2 diabetes, alcohol, metabolic syndrome
→ Usually asymptomatic initially
→ May progress to steatohepatitis → fibrosis → cirrhosis

Key labs
→ Mild ↑ ALT/AST (ALT > AST in NAFLD)

🟣 Alcoholic Liver Disease

→ Due to chronic alcohol intake

Progression sequence
→ Fatty liver → Alcoholic hepatitis → Cirrhosis

Histology
→ Ballooned hepatocytes
→ Mallory–Denk bodies
→ Neutrophilic infiltration

Labs
→ AST : ALT > 2:1 (classic)

🟣 Hepatitis (Viral / Inflammatory)

→ Inflammation of liver parenchyma

Causes
→ Viral (A, B, C, D, E)
→ Autoimmune
→ Drugs / toxins

Symptoms
→ Fatigue, jaundice, RUQ pain, nausea

Chronic hepatitis may lead to
→ Fibrosis
→ Cirrhosis
→ Hepatocellular carcinoma

🟣 Liver Cirrhosis

→ Irreversible fibrosis with regenerative nodules

Major consequences
→ Portal hypertension
→ Ascites
→ Varices
→ Hepatic encephalopathy
→ Coagulopathy

Common causes
→ Alcohol
→ Chronic hepatitis B/C
→ NAFLD

🟣 Hepatocellular Carcinoma (HCC)

→ Primary liver malignancy
→ Usually develops on cirrhotic liver

Risk factors
→ Chronic HBV/HCV
→ Alcohol
→ NAFLD

Features
→ Weight loss
→ RUQ pain
→ Rising AFP (alpha-fetoprotein)
→ Vascular invasion common

🟣 Cholestasis / Bile Duct Obstruction

→ Impaired bile flow

Clinical features
→ Pruritus
→ Pale stools
→ Dark urine
→ Jaundice

Labs
→ ↑ ALP
→ ↑ GGT
→ ↑ Direct bilirubin

Causes
→ Gallstones
→ Tumors
→ Strictures
→ Primary biliary cholangitis

🟣 Acute Liver Failure

→ Rapid loss of liver function

Defined by
→ Encephalopathy
→ Coagulopathy (↑ INR)

Causes
→ Acetaminophen toxicity (most common)
→ Viral hepatitis
→ Drugs / toxins

Histology
→ Massive hepatocyte necrosis

Medical emergency.

🟣 Primary Biliary Cholangitis (PBC)

→ Autoimmune destruction of intrahepatic bile ducts

Typical patient
→ Middle-aged woman

Labs
→ ↑ ALP
→ Positive antimitochondrial antibodies (AMA)

Leads to
→ Progressive cholestasis
→ Cirrhosis

🟣 Portal Hypertension

→ Increased pressure in portal venous system (usually due to cirrhosis)

Consequences
→ Splenomegaly
→ Ascites
→ Esophageal varices
→ Caput medusae

Mechanism
→ Increased intrahepatic resistance + collateral formation

05/02/2026

Nutritional Neuroscience: Micronutrients in Neurotransmitter Synthesis and Metabolism- A Simple Illustration.

Understanding the complex interplay between vitamins, minerals, and neurotransmitter pathways highlights the foundational role of nutrition in cognitive health and overall well-being.

02/02/2026

🩺 SURGERY TRIADS

🔹 Charcot’s Triad

(Ascending cholangitis – biliary tract infection)

Components

→ Fever
→ Right upper quadrant abdominal pain
→ Jaundice

Pathophysiology

Obstruction of the common bile duct (usually gallstones) → bacterial infection → biliary sepsis.

Clinical pearls

• Most commonly caused by choledocholithiasis
• Common organisms: E. coli, Klebsiella, Enterococcus
• Medical emergency

⭐ If hypotension + altered mental status are added → Reynolds pentad (severe septic cholangitis)

🔹 Virchow’s Triad

(Mechanism of thrombosis)

Components

→ Stasis of blood flow
→ Endothelial injury
→ Hypercoagulability

Explanation

Any one—or combination—predisposes to venous or arterial thrombosis.

Examples

• Stasis: prolonged immobilization, heart failure
• Endothelial injury: trauma, surgery, smoking
• Hypercoagulability: malignancy, pregnancy, thrombophilia

⭐ Foundation for understanding DVT and pulmonary embolism.

🔹 Beck’s Triad

(Acute cardiac tamponade)

Components

→ Hypotension
→ Jugular venous distension
→ Muffled heart sounds

Pathophysiology

Rapid accumulation of pericardial fluid compresses the heart → reduced cardiac output.

Clinical pearls

• Causes: trauma, malignancy, uremia, post-MI
• Pulsus paradoxus often present
• Requires urgent pericardiocentesis

🔹 Saint’s Triad

(Classical association – not causal)

Components

→ Gallstones
→ Hiatus hernia
→ Diverticulosis of colon

Note

This is a historical association seen in elderly patients.
No proven pathophysiological link.

⭐ Important for exams but clinically coincidental.

🔹 Cushing’s Triad

(Raised intracranial pressure)

Components

→ Hypertension (widened pulse pressure)
→ Bradycardia
→ Irregular respirations

Pathophysiology

Raised ICP → brainstem compression → autonomic response.

Seen in

• Head injury
• Intracranial hemorrhage
• Brain tumors
• Hydrocephalus

⭐ Indicates impending brain herniation — neurosurgical emergency.

🔹 Portal Hypertension Triad
Components

→ Ascites
→ Splenomegaly
→ Varices (especially esophageal)

Pathophysiology

Increased portal venous pressure (commonly due to liver cirrhosis) → collateral circulation + fluid accumulation.

Clinical pearls

• Varices can cause life-threatening GI bleeding
• Splenomegaly leads to thrombocytopenia
• Ascites from sodium/water retention + portal pressure

16/12/2025

បើបងទៅឆែកសុខភាព រាល់ 6ខែ ឬ 12ខែម្តង សូមបងធ្វើ រឿងសាមញ្ញ 2នេះទៀត ដើម្បីការពារ ការលើសខ្លាញ់ ស្ករ និង អាស៊ីត។

04/12/2025

⚠️ ក្រសួងសុខាភិបាលប្រកាសអាសន្ន៖ រាល់រយៈពេល ៤០នាទីម្តង មានមនុស្សស្លាប់ដោយមហារីក ដោយសារញាំបាយប្រអប់ស្នោរ ម្ហូបក្តៅៗច្រកចានជ័រ ថង់ជ័រ ជាមូលហេតុធំកេីតមហារីក ឥទ្ធិពលនៃប្លាស្ទិក

02/06/2025

#ថ្នាំចាក់ជំនាន់ថ្មីសំរាប់អ្នកជំងឺទឹកនោមផ្អែមប្រភេទទី២

កាលពីមុនតែកាលណាគេតែកាលណាគេនិយាយអំពីថ្នាំចាក់សំរាប់អ្នកជំងឺទឹកនោមផ្អែម គឺគេនិយាយអំពី អាំងស៊ុយលីន។ លែងពិតទៀតហេីយពេលនេះ!

អ្នកប្រាជ្ញ បានរកឃេីញថ្នាំចាក់ជំនាន់ថ្មីសំរាប់អ្នកជំងឺទឹកនោមផ្អែមប្រភេទី២។ តែថ្នាំចាក់ប្រភេទថ្មីនេះ មិនអាចប្រេីបានទេសំរាប់អ្នកជំងឺទឹកនោមផ្អែមប្រភេទទី១ និង ជំងឺទឹកនោមផ្អែមអំទ្បុងពេលមានផ្ទៃពោះ។

ក្រុមថ្នាំនេះ (GLP1-RAs) បញ្ចុះជាតិស្ករ តាមរយះ យន្តការមួយចំនួន:
⁃ ជំរុញអោយមានការបញ្ចេញអាំងស៊ុយលីន (តែវាបញ្ចេញតែពេលជាតិស្ករច្រេីនពេកតែប៉ុណ្ណោះ)
⁃ បន្ថយការបញ្ចេញគ្លុយកាហ្គុង (អ័រម៉ូននាំអោយជាតិស្ករក្នុងឈាមខ្ពស់)
⁃ បន្ថយការឃ្លាន និង នាំអោយស្រកទំងន់
⁃ បន្ថយការបញ្ចេញអាហារពីក្រពះទៅ ពោះវៀន (ជាហេតុនាំអោយជាតិស្ករមិនទ្បេីងខ្លាំងក្រោយអាហារ)

ក្រៅពីបញ្ចុះជាតិស្ករ ក្រុមថ្នាំចាក់ប្រភេទថ្មីនេះ មានប្រយោជន៏ផ្សេងទៀត សំរាប់អ្នកជំងឺទឹកនោមផ្អែមប្រភេទទី២ ដូចជា ការពារជំងឺបេះដូង សរសៃឈាម បានយ៉ាងច្រេីន ហេីយក៏មានការការពារតំរងនោមអ្នកជំងឺផងដែរ។

ក្រុមថ្នាំចាក់ថ្មីនេះ មាន ចាក់១ថ្ងៃ១ម្ជុល មាន១អាទិត្យ១ម្ជុល។

សមាគមជំងឺទឹកនោមផ្អែមធំៗ ណែរនាំអោយប្រេីក្រុមថ្នាំនេះ ជាពិសេសចំពោះអ្នកជំងឺទឹកនោមផ្អែមប្រភេទទី២ ដែលមានហានិភ័យជំងឺបេះដូងសសៃឈាម ខ្ពស់ រឺ ក៏មានជំងឺបេះដូងសសៃឈាមរួចហេីយ។

សូមប្រឹក្សារជាមួយវេជ្ជបណ្ឌិតលោកអ្នកជាមុនសិន មុនហ្នឹងទទួលប្រេីប្រាស់ក្រុមថ្នាំចាក់ថ្មីនេះ!
&N

14/02/2025

15 Lessons from the book titled: How to Become CEO: The Rules for Rising to the Top of Any Organization by Jeffrey J. Fox

1. Master the Basics First
Before seeking a leadership position, Fox emphasizes the importance of mastering the fundamental skills of the job. Understanding the core functions of your role and excelling at them creates a strong foundation for future advancement.

2. Take Initiative and Demonstrate Leadership
To rise to the top, you must demonstrate leadership qualities at every stage of your career. Fox advises taking initiative, offering solutions, and stepping up to challenges even before being asked. It’s not enough to just perform well; you must show you’re capable of leading.

3. Know Your Company's Numbers
Fox stresses that understanding the financials and key performance metrics of your organization is crucial. CEOs need to be able to make data-driven decisions, and understanding how to measure success and profitability is essential to advancing to the top.

4. Build a Strong Network
Networking is a vital part of career progression. Fox recommends building relationships at all levels, from peers to mentors, and connecting with individuals outside your immediate team. A broad and supportive network will help you when it’s time to make strategic career moves.

5. Stay Focused on the Big Picture
While attention to detail is important, Fox encourages aspiring leaders to always keep an eye on the bigger picture. Successful CEOs are able to prioritize long-term goals over short-term tasks and make decisions that align with the company’s vision.

6. Be Results-Oriented
A key to rising in an organization is delivering measurable results. Fox advises focusing on outcomes that drive company growth and showing tangible achievements. Being results-oriented earns you respect and creates opportunities for advancement.

7. Have Integrity and Be Trustworthy
Integrity is a cornerstone of leadership. Fox emphasizes that leaders who are trustworthy, ethical, and transparent in their actions build credibility and earn the respect of others. This trust is a key component in being considered for the top leadership position.

8. Learn the Art of Delegation
Effective leaders don’t try to do everything themselves. Fox highlights the importance of delegation—identifying the right people for the right tasks and empowering them to do their jobs. Delegation allows leaders to focus on high-level strategy while others handle ex*****on.

9. Be Adaptable and Open to Change
Fox stresses that a CEO must be able to adapt to changing circumstances, whether that’s shifts in the market, organizational restructuring, or evolving technologies. Flexibility and a willingness to embrace change are critical for both personal growth and organizational success.

10. Think Like a CEO from the Start
One of the key lessons is to think like a CEO early in your career. This means having a strategic mindset, taking ownership of your career trajectory, and focusing on opportunities that align with your long-term goals. By thinking and acting with the mindset of a CEO, you position yourself for leadership roles in the future.

16/12/2024

A groundbreaking stem cell procedure has reversed Type 1 diabetes in a woman in China, marking a major medical milestone:

Researchers used the woman’s own cells, reprogramming them into insulin-producing stem cells.

As a result, she began producing insulin naturally for the first time since developing the condition. This breakthrough offers new hope for millions with Type 1 diabetes, who currently depend on insulin therapy to manage their blood sugar levels.

The study involved three patients with Type 1 diabetes. Scientists extracted cells from each patient, converted them into stem cells capable of transforming into any cell type, and chemically reprogrammed them into insulin-producing cells.

These newly created cells were then placed inside the patients’ stomachs, where they began producing insulin. While it’s early days, the success with the first patient suggests a future where Type 1 diabetics may no longer need insulin injections to survive.

Learn more: https://www.emjreviews.com/diabetes/news/stem-cell-therapy-success-in-china-marks-milestone-in-type-1-diabetes-treatment/ #:~:text=Stem%2DCell%20Therapy%20Success%20in,in%20Type%201%20Diabetes%20Treatment&text=IN%20A%20GROUNDBREAKING%20medical%20achievement,reducing%20her%20reliance%20on%20injections.

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