Ciencia en Acción: Química y Salud

07/06/2026

Alta poesía

06/06/2026

06/06/2026

New this week! Artificial intelligence–assisted urine cytology based on the for Reporting Urothelial Carcinoma https://acsjournals.onlinelibrary.wiley.com/doi/full/10.1002/cncy.70120

Authored by Lan Chen MD, PhD, Xinyi Cao BS, Zongyue Lu BS, Longteng Liu MSc, Mingjun Sun BS, Yulong Wu BS, and Wei Zhang PhD

Abstract
Background
Urine cytology is a noninvasive and valuable tool for detecting urothelial carcinoma but suffers from variable sensitivity and observer dependency. Artificial intelligence (AI) may enhance the diagnostic accuracy and efficiency of urine cytology. The objective of this study was to develop and validate an AI-based cytology system for urothelial carcinoma detection in both clinical and screening contexts.

Methods
In total, 328 retrospective clinical cases and 1489 prospective health screening samples were analyzed. All specimens underwent liquid-based cytology and were digitized at ×20 magnification. For model development, ed 269 annotated training slides (56,710 cells) were used. The AI pipeline mimicked cytopathologist workflow, integrating deep learning–based cell detection and segmentation with feature extraction and support vector machine classification into AI-negative, AI-atypical, and AI-positive categories according to The Paris System for Reporting the Urinary Cytology. Agreement was assessed using weighted κ values and prevalence-adjusted, bias-adjusted κ values.

Results
In the clinical cohort, AI achieved 83.0% agreement with histopathology and 82.6% agreement with expert cytology. Weighted κ values (κ, 0.631–0.661) reflected substantial agreement, with discrepancies mainly between adjacent categories. In the health screening cohort, the prevalence-adjusted, bias-adjusted κ was 0.647 despite low prevalence. AI demonstrated a high negative predictive value of 99.7% and negative percent agreement of 82.3%, with a minimal false-omission rate (0.25%).

Conclusions
AI-assisted urine cytology exhibited substantial concordance with expert interpretation and histopathologic standards. Its capability of screen-out and high negative predictive value support its potential as a reliable triage tool, improving workflow efficiency while maintaining diagnostic reliability in large-scale screening.

06/06/2026

🦟🔬 ¿Qué son los flebotominos?

Pequeños y casi imperceptibles, los flebotominos son insectos de apenas unos milímetros de longitud. Se distinguen por sus alas en forma de "V", largas patas y cuerpo cubierto de finos pelos.

🌿 Tanto machos como hembras se alimentan de azúcares de plantas, pero las hembras necesitan sangre para producir sus huevos. Gracias a este hábito, algunas especies pueden transmitir parásitos, bacterias y virus de importancia médica.

⚠️ Los flebotominos son los principales vectores de Leishmania, el agente causal de la leishmaniasis, una enfermedad que afecta a millones de personas en regiones tropicales y subtropicales.

🔎 Aunque son diminutos, su impacto en la salud pública es enorme.

Fuente: Ready, P. D. (2013). Biology of phlebotomine sand flies as vectors of disease agents. Annual Review of Entomology, 58, 227-250. https://doi.org/10.1146/annurev-ento-120811-153557

05/06/2026

Ante todo el respeto al personal de salud, que hace lo humanamente posible para la atención.

05/06/2026

Hemocytometer Cell Count, WBC RBC Platelet Counting Made Easy

🧪 Hemocytometer counting is one of the most important manual skills in hematology. Understanding the correct counting areas, dilution factors, and calculation formulas helps ensure accurate WBC, RBC, and platelet results.

📌 Key Points:

1. WBCs are counted in the 4 large corner squares.
2. Platelets are counted in the entire central large square.
3. RBCs are counted in 5 small squares within the center grid.
4. Chamber depth is always 0.1 mm.
5. Final count depends on cells counted, area, depth, and dilution factor.

💡 Save this infographic for quick revision before practical exams, competency assessments, or laboratory training sessions.

What is the most challenging manual cell count for you: WBC, RBC, or Platelets?

05/06/2026

✨ Las luciérnagas son uno de los insectos más sorprendentes de la naturaleza.

Su capacidad para producir luz natural no solo crea paisajes increíbles durante la noche, sino que también cumple funciones importantes como comunicación, reproducción y supervivencia 🌿

Cada especie posee patrones luminosos distintos, y muchas utilizan destellos específicos para reconocer a otros individuos de su misma especie.

Además, las luciérnagas suelen aparecer en ambientes poco contaminados, por lo que también son consideradas indicadores naturales de ecosistemas saludables 🌎

Aunque parecen delicadas, sus larvas viven bajo el suelo y se alimentan de pequeños invertebrados antes de convertirse en adultos brillantes.

La naturaleza todavía guarda criaturas realmente fascinantes ✨

04/06/2026

💊🧪 AROMATIC COMPOUNDS IN MEDICINES & HEALTHCARE | PART 2 🧪💊

Have you ever wondered why so many life-saving medicines contain aromatic rings?

🔬 Aromatic compounds form the molecular backbone of countless pharmaceuticals used worldwide. Their unique stability, biological activity, and versatility make them essential building blocks in modern drug discovery and healthcare.

From pain relievers and antibiotics to cardiovascular medicines and advanced therapeutics, aromatic chemistry continues to improve and save millions of lives every day.

✨ In this poster, explore:

✔️ Aromatic compounds in pharmaceutical science
✔️ Aspirin, Paracetamol & Ibuprofen
✔️ Antibiotics and antimicrobial agents
✔️ Drug design and medicinal chemistry
✔️ Why aromatic rings enhance biological activity
✔️ The role of aromatic molecules in healthcare innovation
✔️ Modern medicines built on aromatic chemistry

💡 Did You Know?

A large proportion of approved pharmaceutical drugs contain at least one aromatic ring, highlighting the importance of aromatic chemistry in modern medicine and healthcare.

🌍 From hospitals and research laboratories to pharmacies and biotechnology companies, aromatic compounds play a crucial role in improving human health worldwide.

📚 Perfect for chemistry students, pharmacy students, medical students, researchers, educators, healthcare professionals, and science enthusiasts.

❤️ Save • Share • Learn

📌 Follow for premium chemistry, medicinal chemistry, and STEM education content.

04/06/2026

Recordemos que cada "muestra" es una vida 🥰🥰🥰

Recuerda que cada laminilla es una mujer esperando recibir un resultado confiable. Dedícale el tiempo suficiente a cada vida.

03/06/2026

Pipetting Technique, Why Small Angle Errors Change Results

🧪 One Wrong Position Changes Sample Accuracy
Pipetting depth and angle directly affect the volume you aspirate. Even small mistakes lead to unreliable laboratory results.

📌 Correct Technique
1️⃣ Keep the pipette vertical
2️⃣ Immerse tip 1–2 mm below surface
3️⃣ Maintain consistent depth every time

⚠️ Common Pipetting Errors
• Deep immersion aspirates excess liquid
• Tilted pipette lowers precision
• Inconsistent depth affects reproducibility

✅ Good pipetting improves:
• Accurate test results
• Reliable sample volume
• Better laboratory quality control

Save this guide for practicals, internships, and daily bench work.