28/04/2026
Metformin is one of the most prescribed drugs for managing Type 2 Diabetes, but long-term use may lower levels of Vitamin B12.
This matters because Vitamin B12 is essential for nerve health, red blood cell production, and DNA synthesis.
Low B12 from prolonged metformin use may contribute to fatigue, numbness, tingling, memory issues, or even worsen neuropathy.
The effect is often gradual and can go unnoticed for years without monitoring.
Risk may be higher with high doses, long duration of use, and in older adults.
That’s why periodic Vitamin B12 assessment may be important for people taking metformin chronically.
Dietary sources, fortified foods, or supplementation may help when deficiency develops.
The key message isn’t to fear metformin—it remains an important and effective medication.
Rather, it’s about awareness of a preventable nutrient deficiency linked to long-term therapy.
If you use metformin, talk with a healthcare professional about whether Vitamin B12 monitoring makes sense for you.
