Nicola Dean Naturopath Herbalist

Nicola Dean Naturopath Herbalist Healthy living, nutritional information and herbal medicine for thriving in menopause & older age.

Nicola creates a safe, non-judgemental environment in which to tell your story, where you will get a different perspective and negotiate an uniquely individual health plan that is not only effective but sensible and of course, very do-able!

Oh yeah šŸ‘šŸ¼
06/09/2026

Oh yeah šŸ‘šŸ¼

Remember this. What you do for yourself impacts everyone else around you.

Love this info x
31/08/2026

Love this info x

31/08/2026

A new generation of Alzheimer biomarkers is changing how we investigate dementia prevention, and this has delivered significant implications for reinterpreting the role of Ginkgo biloba in this context.

A 2026 Korean study followed 35 people with amyloid PET-positive mild cognitive impairment (MCI) for 18 months: 21 received standardised Ginkgo extract 240 mg/day and 14 received other cognitive enhancers. All Ginkgo-treated patients remained clinically stable, compared with cognitive decline in 57.1% of the comparator group. None receiving Ginkgo progressed to Alzheimer dementia, versus 28.6% of comparators.

More significantly, plasma amyloid-β oligomerisation decreased and amyloid PET burden remained stable with Ginkgo, whereas both measures worsened without it. Although small and retrospective, this is groundbreaking research because it links a herbal intervention to longitudinal changes in both a blood biomarker and serial brain imaging, rather than relying solely on cognitive tests.

This work advances a new model for investigating whether herbs can slow the biology that eventually might produce dementia. Biomarkers such as amyloid and tau PET, plasma phosphorylated tau-217, neurofilament light chain, glial fibrillary acidic protein and MRI-measured brain atrophy can reveal biological change well before dementia becomes apparent. Ginkgo is the first herb to be studied in this way, but the approach could readily be applied to other promising herbs and combinations.

This study actually represents the latest stage of a coherent research program from the same Korean group. In 2025, they reported that adding Ginkgo to donepezil in 101 amyloid PET-confirmed Alzheimer patients improved Mini-Mental State Examination scores by 2.4 points and reduced plasma amyloid-β oligomerisation more than donepezil alone. Specifically, MDS-OAβ (Multimer Detection System-Oligomerised Amyloid-β) measures how added amyloid-β forms oligomers in a patient’s plasma, providing an indirect blood-based index of amyloid-aggregation tendency that has been associated with cerebral amyloid burden, but does not directly measure brain oligomers.

A second earlier study in 64 amyloid-positive MCI patients found that Ginkgo preserved cognition and daily function, reduced oligomerisation and was associated with no conversions to dementia, compared with 13.6% among patients receiving other cognitive enhancers. A subsequent pooled a**lysis of 165 amyloid-positive patients again associated Ginkgo exposure with better cognitive and functional trajectories and lower amyloid oligomerisation. The consistency is striking, although all studies were retrospective, originated from the same research network and await independent replication.

This provides an important new context for evaluation of the earlier two large negative Ginkgo prevention trials. The Ginkgo Evaluation of Memory (GEM) study followed 3,069 adults aged 75 years or older for a median of 6.1 years but found no reduction in dementia or Alzheimer disease at 240 mg/day of extract. Similarly, the GuidAge study followed for five years 2,854 adults aged over 70 with memory complaints without finding a significant reduction in progression to Alzheimer disease. These negative findings remain valid, but both trials depended primarily on the eventual appearance of clinical dementia, enrolled biologically heterogeneous populations and began treatment quite late in life. Given that Alzheimer pathology develops over decades, even five or six years may be insufficient in older patients for a modest slowing of pathology to translate into fewer dementia diagnoses.

Modern biomarkers allow us to ask the question earlier and more directly: not whether fewer people have crossed over clinical threshold for dementia, but instead whether a herb is actually slowing the underlying disease process. This appears to be what Ginkgo is doing based on the Korean research.

These papers represent an interesting evolution in the Ginkgo story. Rather than studying unselected patients with ā€˜possible Alzheimer disease risk,’ they focus on patients with amyloid PET-confirmed prodromal Alzheimer disease, thereby reducing one of the major weaknesses of previous Ginkgo prevention trials, namely diagnostic heterogeneity.

Although MDS-OAβ remains less widely accepted than the biomarkers within the AT(N) framework, this limitation is partly offset by the use of amyloid PET both to confirm underlying Alzheimer pathology and, in the 18-month study, to measure changes in cerebral amyloid burden over time. The findings therefore do not rest solely on this exploratory plasma marker, although replication using more established measures such as plasma phosphorylated tau-217 and neurofilament light chain would strengthen them.

The AT(N) framework: A = amyloid biomarkers (PET or CSF/plasma Aβ42/40), T = phosphorylated tau (particularly plasma or CSF p-tau217) and N = neurodegeneration (MRI, fluorodeoxyglucose positron-emission tomography (FDG-PET) or neurofilament light chain (NfL)) is being used in most major pharmaceutical trials.

Another key weakness of the Korean studies is their retrospective, non-randomised design, which cannot exclude treatment-selection bias or unmeasured confounding. However, the clinical signal is unusually strong and consistent across cognition, daily functioning and biomarkers.

For more information see:
https://pubmed.ncbi.nlm.nih.gov/41984497/
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1563056/full
https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2025.1639924/full
https://link.springer.com/article/10.1186/s12906-026-05469-1

29/08/2026

I am 63 now, and after three decades as an orthopedic surgeon, I have examined thousands of people in their eighties. Some arrive frail and afraid, others walk in straighter and more confident than patients half their age. They’re still skiing, still gardening, still picking up grandchildren without a second thought. The gap between those two groups is not luck, and it is rarely genetics alone. The same patterns keep showing up in those who are thriving. Here is what they have in common. The most important reasons are lower down in the list… and the ones you might least expect.

1. They never stopped moving. The strongest 80-year-olds in my office did not start exercising at 79. They simply never quit. There may have been a busy stretch, an injury, a hard year, but movement always came back, because it was part of who they were rather than a program they were on. Perhaps they were dancers, farmers, or a postal worker who enjoyed walking on his lunch break. The body honors that kind of consistency. Decades of regular, ordinary movement leave a margin of strength and capacity that a frightened sedentary body simply does not have.

2. They kept lifting something heavy. Almost none of them would call themselves weightlifters, but the ones who stayed strong kept asking their muscles to work against real resistance. Carrying, climbing, hauling, digging, or actual strength training, the form mattered less than the fact that they kept loading their muscles and bones well into later life. The people who guarded both are the ones still standing tall.

3. They protected their ability to balance. Falls are the event that ends independence for so many older adults, and the ones who age well treat balance as a skill worth keeping. They walk on uneven ground instead of avoiding it; they dance, they run, they garden seriously… they do not surrender their stability to fear and a recliner. Balance fades quietly when you stop challenging it; don’t give it the opportunity to fade.

4. They stayed connected to other people. The thriving 80-year-olds are almost never isolated. They might still have a spouse, they certainly have a circle of friends, a community, and a reason to leave the house and be among others. Loneliness is not just sad, it is physically corrosive, and I watch it accelerate decline all the time… especially after the death of a spouse. The people who kept their relationships alive across the decades arrive in my office with something the isolated ones have lost.

5. They have a reason to get up in the morning. Having a sense of purpose is crucial. Purpose is not a soft concept at any age. Purpose drives meaning. The patients who age best are aimed at something, a project, a person, a role, a craft, a cause. They are needed, or they are building, or they are caring for someone. That sense of mattering pulls them through the hard mornings and keeps them from quietly folding in on themselves. When I ask what they are looking forward to, they have an answer. And that matters far more than you could ever imagine. Think… what’s getting you out of bed in the morning. There should be a serious, immediate answer.

6. They take problems seriously early. When something starts to go wrong, a sore hip, a stumble, a new weakness, the ones who do well do not wait and hope. They address it while it is still small and hopefully reversible. They intuitively understand what I have learned from watching thousands of patients: that a fall leads to a fracture, a fracture leads to bed rest, bed rest leads to weakness, and weakness leads to the next fall.

7. They made peace with getting older without surrendering to it. The strongest 80-year-olds hold a particular balance. They are realistic about their age; they do not pretend to be 40, yet they refuse to use age as an excuse to stop. They modify, they adapt, they keep going. They know the difference between an honest limitation and a self-imposed one, and they spend their energy on what's still within their control. That mindset is its own kind of medicine.

None of this requires perfect genes or a perfect life. It requires pointing yourself in the right direction and staying that way long enough for it to matter. The 80-year-olds I admire most were not born different. They made a thousand small choices, over decades, that compounded in their favor. You are making those same choices right now, whether you notice them or not. It is never too late, nor too early, to begin. Your future self will thank you.

The important role of a top functioning glymphatic system- the brains waste clearance tool 🧠
29/08/2026

The important role of a top functioning glymphatic system- the brains waste clearance tool 🧠

A recent study has shown that the brain’s waste clearance system is impaired in people living with ME/CFS, which can lead to brain fog.

Read about the research via the link in the comments.

28/08/2026

This interview is so interesting 🧐

Favourite Fabulous Herbal āœ…šŸ’•
28/08/2026

Favourite Fabulous Herbal āœ…šŸ’•

Here's another clinical pearl for horsechestnut.

If there is one condition where horsechestnut rarely disappoints, it is haemorrhoids. By improving venous tone, reducing capillary leakage and resolving oedema, it addresses the underlying vascular congestion responsible for pain, swelling and bleeding, rather than simply masking symptoms. In clinical practice it is one of the most consistently reliable herbal medicines for acute and chronic haemorrhoids, particularly when combined with measures to minimise straining and improve bowel function. Its reputation is supported not only by centuries of traditional use, but also by clinical studies demonstrating significant improvements in haemorrhoidal pain, bleeding and swelling, making horsechestnut herbal medicine's most dependable remedy for this common condition.

Over nearly 3 decades I have used an enterically-coated tablet combination of horsechestnut, Ginkgo and butcher’s broom (at 3 tablets per day) for haemorrhoids, with close to a 100% success rate. It is so reliable I have even used it diagnostically to distinguish between haemorrhoids and a**l fissure. If the patient doesn’t improve, then it is most likely a**l fissure, for which this combination has little benefit.

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