25/09/2026
Coronary artery disease develops when fatty material called plaque gradually builds up inside the arteries that supply blood to the heart. As plaque accumulates, the artery becomes narrower and less flexible, reducing the amount of oxygen rich blood reaching the heart muscle. This process is known as atherosclerosis and can develop for years before causing obvious symptoms.
The danger increases when a plaque suddenly breaks open. The body responds by sending platelets to the damaged area, where they can form a blood clot. If the clot blocks the artery, blood flow to part of the heart can stop, causing a heart attack. Before that happens, reduced blood flow can also produce angina, often experienced as pressure, squeezing, heaviness or pain in the chest, especially during physical activity.
Several factors can accelerate plaque formation, including high LDL cholesterol, high blood pressure, diabetes, smoking, obesity and increasing age. Over time, cholesterol, inflammatory material and damaged cells accumulate within the artery wall, while the vessel becomes increasingly stiff. The result is a gradual transformation of a healthy blood vessel into one capable of suddenly disrupting the heart's blood supply.