Important EU Project

11/05/2026

📢 The IMPORTANT Trial Newsletter #17 is out!
In this May 2026 edition, we share the latest updates from the IMPORTANT trial, including:
✅ All 13 sites are now open for recruitment
✅ 118 patients included and 109 randomized as of 30 April 2026
✅ Updates on the trial’s adaptive design and patient-centered adaptations
✅ Latest information on the toxicity-driven interim analysis
✅ Key reminders for participating sites and study teams
The IMPORTANT trial continues working to generate high-quality evidence on dose optimization of CDK4/6 inhibitors in older breast cancer patients, helping support more individualized treatment and follow-up approaches in real-world clinical practice.

Funded by the European Union under Horizon Europe grant agreement No. 101104589. The UK participant in Horizon Europe Project IMPORTANT is supported by UKRI grant number 10072029.

16/03/2026

📍 IMPORTANT Trial presented at the EUnetCCC - European Network of Comprehensive Cancer Centres Symposium

We are pleased to share that the IMPORTANT trial poster was presented at the first symposium hosted by the EU-funded Joint Action EUnetCCC - European Network of Comprehensive Cancer Centres, organised in collaboration with the European Academy of Cancer Sciences.

The symposium, “Innovating Cancer Care Through De-escalation Studies”, brought together experts from across Europe to discuss how high-quality de-escalation studies can help optimise cancer treatment while maintaining the best possible outcomes for patients.

The IMPORTANT trial contributes to this discussion by exploring how geriatric assessment can support dose optimisation of CDK4/6 inhibitors in older patients with breast cancer, helping advance more personalised and patient-centred treatment strategies.

12/03/2026

🚀 IMPORTANT Trial – Recruitment Milestone
We are excited to share that the IMPORTANT trial (IMPlementing geriatric assessment for dose Optimization of CDK4/6 inhibitors in older bReasT cAncer patieNTs) continues to make strong progress.

👥 101 patients have been enrolled so far
🏥 13 clinical sites are currently open for recruitment

Collaboration across Europe is helping accelerate evidence generation to optimize treatment for older breast cancer patients.
A big thank you to all clinical teams, partners and patients contributing to this important effort. Every patient enrolled brings us one step closer to improving more personalized cancer care.

10/03/2026

🎥 New video: Why dose optimisation matters for older people living with advanced breast cancer

Older patients can benefit from combining CDK4/6 inhibitors with endocrine therapy, but they may also face a higher risk of side effects and treatment discontinuation.

The IMPORTANT project is generating real-world evidence through a pragmatic, decentralised clinical study, exploring lower initial dosing strategies and focusing on what matters most for patients: tolerability, prognosis and quality of life.

Our research supports shared decision-making between patients and healthcare professionals, helping to ensure treatments are both effective and manageable for older people living with advanced breast cancer.

📢 Follow the IMPORTANT project to stay updated on our research, videos and insights.



Funded by the European Union (Grant Agreement No. 101104589). Views and opinions expressed are those of the author(s) only and do not necessarily reflect those of the European Union or the granting authority. Neither the European Union nor the granting authority can be held responsible for them.

17/02/2026

IMPORTANTProject at the EUnetCCC – European Network of Comprehensive Cancer Centres Symposium on Cancer Treatment De-escalation

We are pleased to announce that the IMPORTANT Project will participate in the two-day on-site symposium:

'Innovating Cancer Care Through De-escalation Studies'
📅 5–6 March 2026
📍 Netherlands Cancer Institute (NKI), Amsterdam

Hosted by the EU-funded Joint Action EUnetCCC, in collaboration with the European Academy of Cancer Sciences, this symposium will gather up to 200 leading experts — including clinicians, researchers, bioinformaticians, healthcare professionals, patient representatives, policymakers and industry stakeholders.
The focus: advancing high-quality cancer treatment de-escalation studies across Europe.

Cancer treatment de-escalation aims to safely reduce treatment intensity while maintaining optimal patient outcomes. As a Horizon Europe-funded clinical trial, the IMPORTANT study contributes directly to this effort by investigating personalised dose optimisation strategies for older patients with advanced HR+/HER2- breast cancer.

By contributing to this important dialogue, we aim to help shape more patient-centred, evidence-based, and sustainable cancer care across Europe.

We look forward to engaging discussions and collaborative exchange in Amsterdam.

11/02/2026

🎯 Optimising Treatment for Older Patients with Breast Cancer

🔗 Watch the video here: https://www.youtube.com/watch?v=j4M20d68Lkw

Older patients with metastatic breast cancer remain underrepresented in clinical trials — despite representing a significant and growing population.

The IMPORTANT EU Project, funded under the EU Cancer Mission, is addressing this critical gap.

Coordinated by Örebro University and led scientifically by Professor Antonis Valachis, IMPORTANT aims to optimise the dosing of CDK4/6 inhibitors through a pragmatic randomised controlled trial integrating geriatric assessment–based dosing strategies.

By moving beyond the “one-size-fits-all” approach, the project seeks to ensure treatments are both effective and better tolerated for older patients.

🔬 The project will:
• Conduct a multinational clinical trial across six European countries
• Generate high-level evidence on geriatric assessment–guided dosing
• Improve quality of life while maintaining treatment efficacy

🌍 Older patients deserve evidence-based treatments tailored to their specific needs. IMPORTANT contributes to more inclusive, personalised and sustainable cancer care across Europe.

IMPORTANT evaluates personalised dosing strategies for CDK4/6 inhibitors in older patients with metastatic breast cancer using geriatric assessment. The proj...

04/02/2026

🎉 New publication accepted at PERSUASIVE 2026!

The IMPORTANT EU Project is pleased to share that a new research paper has been accepted at the 21st International Conference on Persuasive Technology (PERSUASIVE 2026), taking place March 10–13, 2026 in Hakodate, Japan.

📄 The paper explores an important question:
❓ Why do so many older adults still hesitate to participate in clinical trials?

Decentralised clinical trials aim to improve access and inclusion — but across Europe, healthcare systems and patient support structures differ widely. These local differences strongly shape patients’ decisions to enroll and remain in a trial. In this study, clinicians and patient representatives across six European countries were interviewed to identify what support patients need most — and how digital tools must be adapted to local realities.
✨ Key insights include:
➝ Barriers to participation vary significantly by country and context
➝ “One-size-fits-all” approaches risk overlooking real patient needs
➝ Personalised, human-centred and localised support is essential

The findings inform the development of a Patient Companion App, designed to help older breast cancer patients feel more informed, supported and confident throughout their trial journey.
📍 Conference: PERSUASIVE 2026
🗓 March 10–13, 2026 | Hakodate, Japan
🔗 https://lnkd.in/dZzH2pRZ
This work contributes to:
IMPORTANT — IMPlementing geriatric assessment for dose Optimization of CDK 4/6-inhibitors in older bReasT cAncer patieNTs (Grant Agreement No. 101104589)

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Maryam Rabie Yeganeh

02/02/2026

We are pleased to contribute to the Mission Cancer Cluster Working Group on Citizen Engagement, alongside Horizon Europe projects committed to strengthening the role of citizens, patients, and communities in cancer research.

We are working together with the Mission Cancer Cluster partner projects: LIVERATION, SAGITTARIUS, PragmaTIL, CARE1, PRIME-ROSE, DE-ESCALATE, IntReALL2020, LEGATO, IMPACT-AML, SALVOVAR, and STREXIT2.

Through this cluster collaboration, the IMPORTANT EU Project supports joint efforts to enhance meaningful citizen and patient involvement, exchange best practices, and address common challenges in engagement across Europe.

Citizen engagement is central to the Mission Cancer vision — ensuring research and innovation are developed with and for the people they aim to serve.

30/01/2026

Newsletter #15 is out!
We are pleased to share the January 2026 edition of the IMPORTANT trial newsletter – a Horizon Europe–funded project advancing personalized care for older patients with breast cancer.

Key updates include:
✔️ 93 patients recruited so far, with all 13 sites open and active
✔️ A toxicity-driven interim analysis planned at 100 patients to assess dose optimization strategies
✔️ Expansion of the network with four new satellite sites in Sweden starting in early 2026
✔️ Ongoing oversight by an independent Data Monitoring Committee (IDMC) to ensure patient safety
✔️ Continued progress toward implementing geriatric assessment–guided treatment in real-world clinical settings
The IMPORTANT trial is a collaborative European effort aiming to improve outcomes, quality of life and treatment tolerability for older adults receiving CDK4/6 inhibitors.
👉 Follow the project and stay updated:
🔗 https://lnkd.in/dJqrjmWx
🔗 Bluesky: https://lnkd.in/dQrtsX-d
🔗 X: https://lnkd.in/dauu5vHf

This project is funded by the European Union’s Horizon Europe research and innovation programme under Grant Agreement No. 101104589

30/01/2026

💡 Improving treatment tolerability for older adults with breast cancer

Older patients benefit from CDK4/6 inhibitors, but often experience higher toxicity and treatment discontinuation.

The IMPORTANT trial is addressing this gap by implementing geriatric assessment–guided dose optimization in a pragmatic, real-world clinical trial setting.

The goal: better outcomes, improved quality of life, and more individualized care for older adults.

🌍 Learn more about the project: https://important-project.com/

This project is funded by the European Union’s Horizon Europe research and innovation programme under Grant Agreement No. 101104589.

IMPORTANT Project IMPlementing geriatric assessment for dose Optimization of CDK 4/6-inhibitors in older bReasT cAncer patieNTs The Vision To design and conduct a pragmatic clinical study with a decentralised approach for older patients (both male and female) with refractory advanced HR+/HER2- negat...