03/06/2026
Newer targeted chemotherapy medications have been found to cause significant corneal toxicity. 👁️
“Chemotherapy works by attacking the rapidly growing cancer cells and will have a more significant effect on any rapid-growing cell in the body, which is why people lose their hair, etc.,” says Eric Donnenfeld, MD. “The ocular surface is one of the more rapid-growing tissues in the eye. The lacrimal glands, the conjunctival and corneal epithelium, and the meibomian glands are all rapidly replicating, and because of this, they sometimes will be damaged as a side effect of chemotherapy. Inflammation also plays a role in chemotherapy, which can disrupt the tear film, and some chemotherapies actually have a neurotoxic effect. They affect the nerves of the eye, as well.”
Learn more in the feature, "Ocular Side Effects of Chemotherapy Drugs," available in the May issue or online at www.reviewofophthalmology.com. 📖